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- W2021012275 abstract "ABSTRACT Tuberculosis remains a global health threat, and there is dire need to develop a vaccine that is safe and efficacious and confers long-lasting protection. In this study, we constructed recombinant attenuated Salmonella vaccine (RASV) strains with plasmids expressing fusion proteins consisting of the 80 amino-terminal amino acids of the type 3 secretion system effector SopE of Salmonella and the Mycobacterium tuberculosis antigens early secreted antigenic target 6-kDa (ESAT-6) protein and culture filtrate protein 10 (CFP-10). We demonstrated that the SopE-mycobacterial antigen fusion proteins were translocated into the cytoplasm of INT-407 cells in cell culture assays. Oral immunization of mice with RASV strains synthesizing SopE–ESAT-6–CFP-10 fusion proteins resulted in significant protection of the mice against aerosol challenge with M. tuberculosis H37Rv that was similar to the protection afforded by immunization with Mycobacterium bovis bacillus Calmette-Guérin (BCG) administered subcutaneously. In addition, oral immunization with the RASV strains specifying these mycobacterial antigens elicited production of significant antibody titers to ESAT-6 and production of ESAT-6- or CFP-10-specific gamma interferon (IFN-γ)-secreting and tumor necrosis factor alpha (TNF-α)-secreting splenocytes." @default.
- W2021012275 created "2016-06-24" @default.
- W2021012275 creator A5014542226 @default.
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- W2021012275 creator A5051882730 @default.
- W2021012275 creator A5058951265 @default.
- W2021012275 creator A5082190715 @default.
- W2021012275 date "2012-02-01" @default.
- W2021012275 modified "2023-09-25" @default.
- W2021012275 title "Live Attenuated Salmonella Vaccines against Mycobacterium tuberculosis with Antigen Delivery via the Type III Secretion System" @default.
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- W2021012275 doi "https://doi.org/10.1128/iai.05525-11" @default.
- W2021012275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3264309" @default.
- W2021012275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22144486" @default.
- W2021012275 hasPublicationYear "2012" @default.
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