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- W2021013996 abstract "Cationic cyclizations are among the most demanding reactions that have been catalyzed by antibodies. These studies provided valuable mechanistic insights while opening up the possibility of formation of steroidal carbon frameworks. However, they have involved substrates that contained an aryl sulfonate group adjacent to a primary carbon center not observed in natural cationic cyclization processes. This paper presents an extension of our earlier work, now focusing on substrates analogous to those seen in triterpene biosynthesis. Three antibodies, 15D6, 20C7, and 25A10, have been generated by immunization with an 4-aza-steroid aminoxide hapten (termed HA8) that initiate the cationic cyclization of an oxidosqualene derivative and catalyze the formation of ring A of the lanosterol nucleus at neutral pH. Antibody HA8-25A10 kinetically resolved its racemic substrates. Design of the substrate was based on a dual-anchor model for specific binding that consists of displaying a functional group at the head (epoxid..." @default.
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- W2021013996 date "1999-12-18" @default.
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- W2021013996 title "Antibodies Mimic Natural Oxidosqualene−Cyclase Action in Steroid Ring A Formation" @default.
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- W2021013996 doi "https://doi.org/10.1021/ja993054l" @default.
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