Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021014002> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2021014002 endingPage "44" @default.
- W2021014002 startingPage "40" @default.
- W2021014002 abstract "Apoptosis is involved in the development and progression of atherosclerotic lesions. Protein kinase C (PKC) signalling is of importance in atherosclerosis as well as apoptosis. Therefore, we tested the involvement of PKC in lipid-induced apoptosis of human coronary artery endothelial cells (HCAEC). Protein expression of PKC isoforms alpha, beta I, delta, epsilon, and iota was detected, whereas no relevant protein amounts of PKC isoforms beta II, gamma, eta, theta, and zeta were found. Inhibition of classical and novel PKC isoforms by treatment with bisindolylmaleimide or PKC down-regulation by long-term treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) could not prevent apoptosis induced by palmitate or stearate. In contrast, a specific myristoylated, cell-permeable PKC zeta/iota pseudosubstrate prevented lipid-induced apoptosis in HCAEC. Furthermore, saturated fatty acids activated PKC iota as evidenced by PKC iota down-regulation upon long-term treatment with stearate. Our data provide evidence that PKC iota is activated by saturated fatty acids and mediates lipid-induced apoptosis of HCAEC." @default.
- W2021014002 created "2016-06-24" @default.
- W2021014002 creator A5009815366 @default.
- W2021014002 creator A5030642333 @default.
- W2021014002 creator A5036886342 @default.
- W2021014002 creator A5041173108 @default.
- W2021014002 creator A5056012072 @default.
- W2021014002 creator A5062734974 @default.
- W2021014002 creator A5071533961 @default.
- W2021014002 creator A5081400849 @default.
- W2021014002 creator A5084404405 @default.
- W2021014002 date "2009-06-01" @default.
- W2021014002 modified "2023-09-26" @default.
- W2021014002 title "Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells" @default.
- W2021014002 cites W1577885098 @default.
- W2021014002 cites W1608134522 @default.
- W2021014002 cites W1989911355 @default.
- W2021014002 cites W2011718377 @default.
- W2021014002 cites W2066032479 @default.
- W2021014002 cites W2069401919 @default.
- W2021014002 cites W2076503506 @default.
- W2021014002 cites W2104726084 @default.
- W2021014002 cites W2130519693 @default.
- W2021014002 cites W2147552765 @default.
- W2021014002 cites W2151680322 @default.
- W2021014002 cites W2153747542 @default.
- W2021014002 cites W2159157105 @default.
- W2021014002 cites W2162887701 @default.
- W2021014002 cites W2168224573 @default.
- W2021014002 cites W2171988255 @default.
- W2021014002 doi "https://doi.org/10.1016/j.mvr.2009.01.014" @default.
- W2021014002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19327373" @default.
- W2021014002 hasPublicationYear "2009" @default.
- W2021014002 type Work @default.
- W2021014002 sameAs 2021014002 @default.
- W2021014002 citedByCount "6" @default.
- W2021014002 countsByYear W20210140022014 @default.
- W2021014002 countsByYear W20210140022015 @default.
- W2021014002 countsByYear W20210140022022 @default.
- W2021014002 crossrefType "journal-article" @default.
- W2021014002 hasAuthorship W2021014002A5009815366 @default.
- W2021014002 hasAuthorship W2021014002A5030642333 @default.
- W2021014002 hasAuthorship W2021014002A5036886342 @default.
- W2021014002 hasAuthorship W2021014002A5041173108 @default.
- W2021014002 hasAuthorship W2021014002A5056012072 @default.
- W2021014002 hasAuthorship W2021014002A5062734974 @default.
- W2021014002 hasAuthorship W2021014002A5071533961 @default.
- W2021014002 hasAuthorship W2021014002A5081400849 @default.
- W2021014002 hasAuthorship W2021014002A5084404405 @default.
- W2021014002 hasConcept C104317684 @default.
- W2021014002 hasConcept C185592680 @default.
- W2021014002 hasConcept C190283241 @default.
- W2021014002 hasConcept C195794163 @default.
- W2021014002 hasConcept C2780043322 @default.
- W2021014002 hasConcept C53345823 @default.
- W2021014002 hasConcept C55493867 @default.
- W2021014002 hasConcept C62478195 @default.
- W2021014002 hasConcept C86803240 @default.
- W2021014002 hasConcept C95444343 @default.
- W2021014002 hasConceptScore W2021014002C104317684 @default.
- W2021014002 hasConceptScore W2021014002C185592680 @default.
- W2021014002 hasConceptScore W2021014002C190283241 @default.
- W2021014002 hasConceptScore W2021014002C195794163 @default.
- W2021014002 hasConceptScore W2021014002C2780043322 @default.
- W2021014002 hasConceptScore W2021014002C53345823 @default.
- W2021014002 hasConceptScore W2021014002C55493867 @default.
- W2021014002 hasConceptScore W2021014002C62478195 @default.
- W2021014002 hasConceptScore W2021014002C86803240 @default.
- W2021014002 hasConceptScore W2021014002C95444343 @default.
- W2021014002 hasIssue "1" @default.
- W2021014002 hasLocation W20210140021 @default.
- W2021014002 hasLocation W20210140022 @default.
- W2021014002 hasOpenAccess W2021014002 @default.
- W2021014002 hasPrimaryLocation W20210140021 @default.
- W2021014002 hasRelatedWork W2005377232 @default.
- W2021014002 hasRelatedWork W2026913891 @default.
- W2021014002 hasRelatedWork W2031543068 @default.
- W2021014002 hasRelatedWork W2045619382 @default.
- W2021014002 hasRelatedWork W2084059091 @default.
- W2021014002 hasRelatedWork W2087665954 @default.
- W2021014002 hasRelatedWork W2121428123 @default.
- W2021014002 hasRelatedWork W2121795279 @default.
- W2021014002 hasRelatedWork W2155814150 @default.
- W2021014002 hasRelatedWork W2315281521 @default.
- W2021014002 hasVolume "78" @default.
- W2021014002 isParatext "false" @default.
- W2021014002 isRetracted "false" @default.
- W2021014002 magId "2021014002" @default.
- W2021014002 workType "article" @default.