Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021014123> ?p ?o ?g. }
- W2021014123 endingPage "202" @default.
- W2021014123 startingPage "191" @default.
- W2021014123 abstract "The E proteins and Id proteins are, respectively, the positive and negative heterodimer partners for the basic-helix-loop-helix protein family and as such contribute to a remarkably large number of cell-fate decisions. E proteins and Id proteins also function to inhibit or promote cell proliferation and cancer. Using a genetic modifier screen in Drosophila, we show that the Id protein Extramacrochaetae enables growth by suppressing activation of the Salvador-Warts-Hippo pathway of tumor suppressors, activation that requires transcriptional activation of the expanded gene by the E protein Daughterless. Daughterless protein binds to an intronic enhancer in the expanded gene, both activating the SWH pathway independently of the transmembrane protein Crumbs and bypassing the negative feedback regulation that targets the same expanded enhancer. Thus, the Salvador-Warts-Hippo pathway has a cell-autonomous function to prevent inappropriate differentiation due to transcription factor imbalance and monitors the intrinsic developmental status of progenitor cells, distinct from any responses to cell-cell interactions." @default.
- W2021014123 created "2016-06-24" @default.
- W2021014123 creator A5028529010 @default.
- W2021014123 creator A5089282405 @default.
- W2021014123 date "2015-01-01" @default.
- W2021014123 modified "2023-10-17" @default.
- W2021014123 title "Salvador-Warts-Hippo Pathway in a Developmental Checkpoint Monitoring Helix-Loop-Helix Proteins" @default.
- W2021014123 cites W145923327 @default.
- W2021014123 cites W1494988280 @default.
- W2021014123 cites W1509480763 @default.
- W2021014123 cites W1518616355 @default.
- W2021014123 cites W1566225830 @default.
- W2021014123 cites W1790041644 @default.
- W2021014123 cites W1841999755 @default.
- W2021014123 cites W1956977862 @default.
- W2021014123 cites W1968814136 @default.
- W2021014123 cites W1968887322 @default.
- W2021014123 cites W1969032952 @default.
- W2021014123 cites W1971801159 @default.
- W2021014123 cites W1976990850 @default.
- W2021014123 cites W1978746441 @default.
- W2021014123 cites W1978947310 @default.
- W2021014123 cites W1979222585 @default.
- W2021014123 cites W1980333298 @default.
- W2021014123 cites W1982313327 @default.
- W2021014123 cites W1984282087 @default.
- W2021014123 cites W1987041209 @default.
- W2021014123 cites W1992294689 @default.
- W2021014123 cites W1995420824 @default.
- W2021014123 cites W1998436299 @default.
- W2021014123 cites W2000225283 @default.
- W2021014123 cites W2001565015 @default.
- W2021014123 cites W2002116477 @default.
- W2021014123 cites W2003927747 @default.
- W2021014123 cites W2004102023 @default.
- W2021014123 cites W2006229889 @default.
- W2021014123 cites W2006778392 @default.
- W2021014123 cites W2008680715 @default.
- W2021014123 cites W2009419588 @default.
- W2021014123 cites W2009648600 @default.
- W2021014123 cites W2016591815 @default.
- W2021014123 cites W2016684457 @default.
- W2021014123 cites W2019231065 @default.
- W2021014123 cites W2020495210 @default.
- W2021014123 cites W2033360354 @default.
- W2021014123 cites W2033440293 @default.
- W2021014123 cites W2034071612 @default.
- W2021014123 cites W2034820114 @default.
- W2021014123 cites W2037598426 @default.
- W2021014123 cites W2040853660 @default.
- W2021014123 cites W2041090629 @default.
- W2021014123 cites W2044355018 @default.
- W2021014123 cites W2046930479 @default.
- W2021014123 cites W2046985565 @default.
- W2021014123 cites W2049690785 @default.
- W2021014123 cites W2050666087 @default.
- W2021014123 cites W2053529409 @default.
- W2021014123 cites W2055378633 @default.
- W2021014123 cites W2056069458 @default.
- W2021014123 cites W2056182849 @default.
- W2021014123 cites W2060020667 @default.
- W2021014123 cites W2061183445 @default.
- W2021014123 cites W2063882402 @default.
- W2021014123 cites W2066505201 @default.
- W2021014123 cites W2073568903 @default.
- W2021014123 cites W2083106714 @default.
- W2021014123 cites W2083823591 @default.
- W2021014123 cites W2085197940 @default.
- W2021014123 cites W2085250524 @default.
- W2021014123 cites W2085316173 @default.
- W2021014123 cites W2085625330 @default.
- W2021014123 cites W2086456864 @default.
- W2021014123 cites W2086620281 @default.
- W2021014123 cites W2087021490 @default.
- W2021014123 cites W2087513467 @default.
- W2021014123 cites W2090289340 @default.
- W2021014123 cites W2090330117 @default.
- W2021014123 cites W2091427349 @default.
- W2021014123 cites W2092610731 @default.
- W2021014123 cites W2097192405 @default.
- W2021014123 cites W2099709490 @default.
- W2021014123 cites W2101538557 @default.
- W2021014123 cites W2101927529 @default.
- W2021014123 cites W2103100126 @default.
- W2021014123 cites W2108490725 @default.
- W2021014123 cites W2108558044 @default.
- W2021014123 cites W2117841435 @default.
- W2021014123 cites W2118028844 @default.
- W2021014123 cites W2118671972 @default.
- W2021014123 cites W2119483052 @default.
- W2021014123 cites W2120546609 @default.
- W2021014123 cites W2122382744 @default.
- W2021014123 cites W2126010492 @default.
- W2021014123 cites W2128086399 @default.
- W2021014123 cites W2131413501 @default.
- W2021014123 cites W2132594844 @default.
- W2021014123 cites W2133567026 @default.
- W2021014123 cites W2137236648 @default.