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- W2021016087 abstract "To determine whether the fraction of CD177+ neutrophils might be altered in clonal myeloid disorders, similar to the skewed κ/λ ratio for B-cell lymphomas, and could be used to identify myeloid neoplasms. Blood and bone marrow samples were evaluated for the fraction of CD177+ neutrophils by flow cytometry. Skewed high neutrophil CD177(%) was not associated with neoplasia, but skewed low neutrophil CD177(%) was highly correlated with clonal myeloid disorders at values less than 40%. Specificity of low neutrophil CD177(%) for clonal myeloid disorders was 87% with a 40% cutoff and 95% with a 30% cutoff. Findings were most pronounced for myelodysplasia, with 52% (11/21) containing fewer than 40% CD177+ neutrophils. Specificity was also suggested by normalization of neutrophil CD177(%) in four patients who reached morphologic remission after therapy for myelodysplasia or acute leukemia. Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders." @default.
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- W2021016087 date "2013-11-01" @default.
- W2021016087 modified "2023-10-16" @default.
- W2021016087 title "CD177 Expression on Neutrophils" @default.
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- W2021016087 doi "https://doi.org/10.1309/ajcpdfbebqzw1oi7" @default.
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