FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021016593> ?p ?o ?g. }

• W2021016593 endingPage "2000" @default.
• W2021016593 startingPage "1991" @default.
• W2021016593 abstract "A novel class of targeted chemotherapeutic agents based on cytotoxic compounds linked to LHRH analogs was tested in a long term superfusion system in order to determine their effects on different types of rat pituitary cells. The compounds investigated included two cytotoxic LHRH agonists, T-98 ([D-Lys6]LHRH coupled to glutaryl-2-(hydroxymethyl)anthraquinone (G-HMAQ)) and T-107 ([D-Lys6]LHRH linked to doxorubicin (DOX) through glutaric acid spacer), and two cytotoxic LHRH antagonists T-121 and T-144, both containing two residues of G-HMAQ. The analogs were infused for 24 h at pharmacological (micromolar) concentrations. The secretions of LH, GH, and PRL cells after a short (2-h) and a long (20-h) recovery period following the treatment were compared to those before the analog infusion. All four cytotoxic LHRH analogs selectively decreased the stimulated LH response, while basal secretions of LH, GH, and PRL as well as the stimulated release of GH and PRL were not influenced in spite of the high doses applied and the long duration of exposure. The inhibitory effects of cytotoxic agonists and antagonists were significantly greater than those of their parent peptides. Equimolar concentrations of cytotoxic compounds alone (DOX or G-HMAQ), however, caused functional damage to all types of cells tested. To evaluate the mechanisms of the observed inhibitory actions, we compared the amount of LH released in response to 1) a specific stimulus to receptors (3 nM LHRH), 2) membrane depolarization with 100 MM KCl, not involving the receptor, and 3) the extraction of cells with 0.01 N HCl at the end of experiment. Cytotoxic LHRH agonists and their carriers caused depletion of LH pools, while cytotoxic LHRH antagonists or their parent peptides decreased the available binding sites for LHRH. The inhibitory effect of DOX on stimulated secretion of LH, GH, and PRL in our system could be due to an action on cell membranes. Our work indicates that in the pituitary cell superfusion system, targeted cytotoxic conjugates, based on LHRH analogs, selectively affect LH cells, in contrast to unconjugated cytotoxic compounds, which also damage GH and PRL cells." @default.
• W2021016593 created "2016-06-24" @default.
• W2021016593 creator A5020268469 @default.
• W2021016593 creator A5025841865 @default.
• W2021016593 creator A5065215059 @default.
• W2021016593 creator A5067625265 @default.
• W2021016593 creator A5068739269 @default.
• W2021016593 creator A5089686007 @default.
• W2021016593 date "1993-05-01" @default.
• W2021016593 modified "2023-10-18" @default.
• W2021016593 title "Effect of luteinizing hormone-releasing hormone analogs containing cytotoxic radicals on the function of rat pituitary cells: tests in a long term superfusion system." @default.
• W2021016593 cites W1510433774 @default.
• W2021016593 cites W1539553075 @default.
• W2021016593 cites W1556507600 @default.
• W2021016593 cites W1589498319 @default.
• W2021016593 cites W1673653330 @default.
• W2021016593 cites W1963893506 @default.
• W2021016593 cites W1984112127 @default.
• W2021016593 cites W1986451811 @default.
• W2021016593 cites W1994627453 @default.
• W2021016593 cites W2001035380 @default.
• W2021016593 cites W2002419309 @default.
• W2021016593 cites W2002451105 @default.
• W2021016593 cites W2009910033 @default.
• W2021016593 cites W2009981615 @default.
• W2021016593 cites W2010726861 @default.
• W2021016593 cites W2011695495 @default.
• W2021016593 cites W2016794614 @default.
• W2021016593 cites W2027314789 @default.
• W2021016593 cites W2035215935 @default.
• W2021016593 cites W2041909464 @default.
• W2021016593 cites W2047523295 @default.
• W2021016593 cites W2056174533 @default.
• W2021016593 cites W2056306868 @default.
• W2021016593 cites W2070999156 @default.
• W2021016593 cites W2076883754 @default.
• W2021016593 cites W2078230286 @default.
• W2021016593 cites W2078939599 @default.
• W2021016593 cites W2093001829 @default.
• W2021016593 cites W2093468577 @default.
• W2021016593 cites W2095940550 @default.
• W2021016593 cites W2107960574 @default.
• W2021016593 cites W2114712559 @default.
• W2021016593 cites W2125550130 @default.
• W2021016593 cites W2173351051 @default.
• W2021016593 cites W2563946553 @default.
• W2021016593 doi "https://doi.org/10.1210/endo.132.5.8477650" @default.
• W2021016593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8477650" @default.
• W2021016593 hasPublicationYear "1993" @default.
• W2021016593 type Work @default.
• W2021016593 sameAs 2021016593 @default.
• W2021016593 citedByCount "6" @default.
• W2021016593 countsByYear W20210165932015 @default.
• W2021016593 countsByYear W20210165932016 @default.
• W2021016593 countsByYear W20210165932022 @default.
• W2021016593 crossrefType "journal-article" @default.
• W2021016593 hasAuthorship W2021016593A5020268469 @default.
• W2021016593 hasAuthorship W2021016593A5025841865 @default.
• W2021016593 hasAuthorship W2021016593A5065215059 @default.
• W2021016593 hasAuthorship W2021016593A5067625265 @default.
• W2021016593 hasAuthorship W2021016593A5068739269 @default.
• W2021016593 hasAuthorship W2021016593A5089686007 @default.
• W2021016593 hasConcept C126322002 @default.
• W2021016593 hasConcept C134018914 @default.
• W2021016593 hasConcept C154317977 @default.
• W2021016593 hasConcept C170493617 @default.
• W2021016593 hasConcept C185592680 @default.
• W2021016593 hasConcept C202751555 @default.
• W2021016593 hasConcept C2778575703 @default.
• W2021016593 hasConcept C2779029589 @default.
• W2021016593 hasConcept C55493867 @default.
• W2021016593 hasConcept C71315377 @default.
• W2021016593 hasConcept C71924100 @default.
• W2021016593 hasConcept C86803240 @default.
• W2021016593 hasConceptScore W2021016593C126322002 @default.
• W2021016593 hasConceptScore W2021016593C134018914 @default.
• W2021016593 hasConceptScore W2021016593C154317977 @default.
• W2021016593 hasConceptScore W2021016593C170493617 @default.
• W2021016593 hasConceptScore W2021016593C185592680 @default.
• W2021016593 hasConceptScore W2021016593C202751555 @default.
• W2021016593 hasConceptScore W2021016593C2778575703 @default.
• W2021016593 hasConceptScore W2021016593C2779029589 @default.
• W2021016593 hasConceptScore W2021016593C55493867 @default.
• W2021016593 hasConceptScore W2021016593C71315377 @default.
• W2021016593 hasConceptScore W2021016593C71924100 @default.
• W2021016593 hasConceptScore W2021016593C86803240 @default.
• W2021016593 hasIssue "5" @default.
• W2021016593 hasLocation W20210165931 @default.
• W2021016593 hasLocation W20210165932 @default.
• W2021016593 hasOpenAccess W2021016593 @default.
• W2021016593 hasPrimaryLocation W20210165931 @default.
• W2021016593 hasRelatedWork W1972504921 @default.
• W2021016593 hasRelatedWork W1979660518 @default.
• W2021016593 hasRelatedWork W1996846474 @default.
• W2021016593 hasRelatedWork W2013690930 @default.
• W2021016593 hasRelatedWork W2019833955 @default.
• W2021016593 hasRelatedWork W2033472167 @default.
• W2021016593 hasRelatedWork W2071237287 @default.

• next