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- W2021016812 abstract "ABSTRACT. Fresh erythrocytes from 35 young normotensive individuals (20 males), the offspring of patients with essential hypertension (EH), and from 24 normotensive controls (14 males) were incubated at 37°C in an isotonic buffer with 22 Na. After 80 min, the net influx (net accumulation) of 22 Na was not significantly different in either group, but after 140 min it was significantly higher (8.2%, p <0.01) in erythrocytes from male offspring as opposed to male controls. After both 80 and 140 min of incubation, the net influx of 22 Na was significantly higher in males than in females in the respective groups. During a 60‐minute period the net efflux of 22 Na from preincubated (180 min) erythrocytes in 14 males in the offspring group was not significantly different from that found in 10 male controls. These findings could indicate that little differences exists in vitro between offspring and controls in the unidirectional fluxes across the membrane. The difference between the male groups in the net influx after 140 min could indicate a higher Na content in the intracellular space in the offspring group, as assumption subsequently verified in a follow‐up. The net influx of 22 Na after 140 min was significantly correlated ( R =0.58, p <0.05) to total plasma aldosterone in male controls, but not in the offspring. No differences in the mean concentrations of total aldosterone, plasma and urinary electrolytes or in serum gamma glutamyl transferase were noted between offspring and controls. Abnormal cellular handling of sodium at least in the male offspring of patients with EH for at least two generations may be an important predisposing factor for EH." @default.
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- W2021016812 date "1981-01-12" @default.
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- W2021016812 title "Net Influx and Efflux of <sup>22</sup>Na in Erythrocytes from Normotensive Offspring of Patients with Essential Hypertension" @default.
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- W2021016812 doi "https://doi.org/10.1111/j.0954-6820.1981.tb09780.x" @default.
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