FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021018587> ?p ?o ?g. }

• W2021018587 endingPage "694" @default.
• W2021018587 startingPage "685" @default.
• W2021018587 abstract "Objective: To determine whether there is an association between cytokine and chemokine levels in plasma isolated from the placenta and HIV-1 mother-to-child transmission (MTCT). Design: We designed a case–control study of HIV-infected, pregnant women enrolled in the Malaria and HIV in Pregnancy cohort. Participants were recruited in Blantyre, Malawi, from 2000 to 2004. Patients were women whose children were HIV-1 DNA-positive at birth (in-utero MTCT) or HIV-1 DNA-negative at birth and HIV-1 DNA-positive at 6 weeks postpartum (intrapartum MTCT); controls were women whose children were HIV-1 DNA-negative both at birth and 6 weeks postpartum. Methods: After delivery, blood was isolated from an incision on the basal plate of the placenta. We used a Bio-Plex human cytokine assay (Bio-Rad, Hercules, California USA) to simultaneously quantify 27 cytokines, chemokines and growth factors in placental plasma. HIV-1 RNA copies were quantified with the Roche Amplicor kit. Results: Levels of interleukin (IL) 4, IL-5, IL-6, IL-7, IL-9, eotaxin, IL-1Ra and interferon gamma-induced protein 10 (IP-10) were significantly elevated in placental plasma isolated from cases of in-utero HIV-1 MTCT. In contrast, only granulocyte colony-stimulating factor was elevated in placental plasma isolated from cases of intrapartum MTCT. After adjusting for maternal age, gestational age and peripheral CD4+ T-cell count, every log10 increase in placental IP-10 was associated with a three-fold increase in the prevalence of in-utero HIV-1 MTCT. Conclusion: Elevated cytokine and chemokine levels in placental plasma were associated with in-utero and not intrapartum MTCT. IP-10, which is both a T-cell chemokine and potentiator of HIV-replication, was robustly and independently associated with prevalent, in-utero MTCT." @default.
• W2021018587 created "2016-06-24" @default.
• W2021018587 creator A5018200433 @default.
• W2021018587 creator A5026367208 @default.
• W2021018587 creator A5033692318 @default.
• W2021018587 creator A5041782217 @default.
• W2021018587 creator A5048718528 @default.
• W2021018587 creator A5052739920 @default.
• W2021018587 creator A5055906233 @default.
• W2021018587 creator A5074496148 @default.
• W2021018587 date "2012-03-27" @default.
• W2021018587 modified "2023-10-07" @default.
• W2021018587 title "Elevated cytokine and chemokine levels in the placenta are associated with in-utero HIV-1 mother-to-child transmission" @default.
• W2021018587 cites W1267291552 @default.
• W2021018587 cites W1502449443 @default.
• W2021018587 cites W1544497380 @default.
• W2021018587 cites W1596523720 @default.
• W2021018587 cites W1676812023 @default.
• W2021018587 cites W1963559980 @default.
• W2021018587 cites W1965086604 @default.
• W2021018587 cites W1982280354 @default.
• W2021018587 cites W1994829994 @default.
• W2021018587 cites W2006266678 @default.
• W2021018587 cites W2016765594 @default.
• W2021018587 cites W2021986727 @default.
• W2021018587 cites W2029445248 @default.
• W2021018587 cites W2036890038 @default.
• W2021018587 cites W2040810722 @default.
• W2021018587 cites W2047385013 @default.
• W2021018587 cites W2050293562 @default.
• W2021018587 cites W2050937329 @default.
• W2021018587 cites W2063255034 @default.
• W2021018587 cites W2063353079 @default.
• W2021018587 cites W2067304749 @default.
• W2021018587 cites W2068065580 @default.
• W2021018587 cites W2070751410 @default.
• W2021018587 cites W2073313046 @default.
• W2021018587 cites W2075028789 @default.
• W2021018587 cites W2078489697 @default.
• W2021018587 cites W2081197338 @default.
• W2021018587 cites W2088493593 @default.
• W2021018587 cites W2088907297 @default.
• W2021018587 cites W2095968013 @default.
• W2021018587 cites W2096731679 @default.
• W2021018587 cites W2101464711 @default.
• W2021018587 cites W2110784409 @default.
• W2021018587 cites W2117029013 @default.
• W2021018587 cites W2117641757 @default.
• W2021018587 cites W2123491363 @default.
• W2021018587 cites W2125070883 @default.
• W2021018587 cites W2131609238 @default.
• W2021018587 cites W2132615792 @default.
• W2021018587 cites W2134288695 @default.
• W2021018587 cites W2136459989 @default.
• W2021018587 cites W2145578434 @default.
• W2021018587 cites W2147169218 @default.
• W2021018587 cites W2147315039 @default.
• W2021018587 cites W2153869022 @default.
• W2021018587 cites W2156606063 @default.
• W2021018587 cites W2157014596 @default.
• W2021018587 cites W2161358581 @default.
• W2021018587 cites W2162729318 @default.
• W2021018587 cites W2163773820 @default.
• W2021018587 cites W2165657851 @default.
• W2021018587 cites W2167278513 @default.
• W2021018587 cites W2167858830 @default.
• W2021018587 cites W2170947401 @default.
• W2021018587 cites W2316970929 @default.
• W2021018587 cites W2889457987 @default.
• W2021018587 cites W4254793567 @default.
• W2021018587 cites W4255418661 @default.
• W2021018587 cites W4294250611 @default.
• W2021018587 cites W94371219 @default.
• W2021018587 doi "https://doi.org/10.1097/qad.0b013e3283519b00" @default.
• W2021018587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3505685" @default.
• W2021018587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22301415" @default.
• W2021018587 hasPublicationYear "2012" @default.
• W2021018587 type Work @default.
• W2021018587 sameAs 2021018587 @default.
• W2021018587 citedByCount "27" @default.
• W2021018587 countsByYear W20210185872012 @default.
• W2021018587 countsByYear W20210185872013 @default.
• W2021018587 countsByYear W20210185872014 @default.
• W2021018587 countsByYear W20210185872015 @default.
• W2021018587 countsByYear W20210185872016 @default.
• W2021018587 countsByYear W20210185872017 @default.
• W2021018587 countsByYear W20210185872018 @default.
• W2021018587 countsByYear W20210185872019 @default.
• W2021018587 countsByYear W20210185872020 @default.
• W2021018587 countsByYear W20210185872021 @default.
• W2021018587 countsByYear W20210185872022 @default.
• W2021018587 countsByYear W20210185872023 @default.
• W2021018587 crossrefType "journal-article" @default.
• W2021018587 hasAuthorship W2021018587A5018200433 @default.
• W2021018587 hasAuthorship W2021018587A5026367208 @default.
• W2021018587 hasAuthorship W2021018587A5033692318 @default.
• W2021018587 hasAuthorship W2021018587A5041782217 @default.
• W2021018587 hasAuthorship W2021018587A5048718528 @default.

• next