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• W2021019710 abstract "You have accessJournal of UrologyProstate Cancer: Localized (III)1 Apr 2013675 OUTCOMES OF RADICAL PROSTATECTOMY IN POTENTIAL CANDIDATES FOR ACTIVE SURVEILLANCE AND PREDICTIVE FACTORS OF CLINICALLY INSIGNIFICANT PROSTATE CANCER Seol Ho Choo, Hyun Hwan Sung, Hyeon Jun Jang, Yoon Seok Suh, U Seok Jeong, Wan Song, Ji Young Kim, Dong Soo Ryu, Hwang Gyun Jeon, Minki Baek, Byong chang Jeong, Seong Il Seo, Seong Soo Jeon, Han Yong Choi, and Hyun Moo Lee Seol Ho ChooSeol Ho Choo Seoul, Korea, Republic of More articles by this author , Hyun Hwan SungHyun Hwan Sung Seoul, Korea, Republic of More articles by this author , Hyeon Jun JangHyeon Jun Jang Seoul, Korea, Republic of More articles by this author , Yoon Seok SuhYoon Seok Suh Seoul, Korea, Republic of More articles by this author , U Seok JeongU Seok Jeong Seoul, Korea, Republic of More articles by this author , Wan SongWan Song Seoul, Korea, Republic of More articles by this author , Ji Young KimJi Young Kim Gyeonggi-do, Korea, Republic of More articles by this author , Dong Soo RyuDong Soo Ryu Changwon, Korea, Republic of More articles by this author , Hwang Gyun JeonHwang Gyun Jeon Seoul, Korea, Republic of More articles by this author , Minki BaekMinki Baek Seoul, Korea, Republic of More articles by this author , Byong chang JeongByong chang Jeong Seoul, Korea, Republic of More articles by this author , Seong Il SeoSeong Il Seo Seoul, Korea, Republic of More articles by this author , Seong Soo JeonSeong Soo Jeon Seoul, Korea, Republic of More articles by this author , Han Yong ChoiHan Yong Choi Seoul, Korea, Republic of More articles by this author , and Hyun Moo LeeHyun Moo Lee Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.230AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We analyzed radical prostatectomy findings of candidates for active surveillance to investigate proportion and predictive factors of clinically significant prostate cancer. METHODS We retrospectively reviewed the medical records of 2036 patients who underwent radical prostatectomy for prostate cancer between 1994 and 2011. 233 patients without neoadjuvant therapy were eligible for active surveillance based on Epstein criteria defined as clinically T1 disease, prostate-specific antigen (PSA) density ≤ 0.15ng/mL2, Gleason score ≤ 6, fewer than three cores containing prostate cancer, and up to 50% of cancer involvement in any core. Clinically significant prostate cancer was defined as pathologic Gleason sum ≥ 7 or non-organ confined disease (extracapsular extension or seminal vesicle invasion). We investigated pathologic outcomes and predictive factors for clinically significant prostate cancer. RESULTS Of total 233 cases, patients with pathologic Gleason sum ≥ 7 were 91 (42.1%), extracapsular extension were 11 (4.7%), and seminal vesicle invasion were 3 (1.3%). Patients with clinically significant prostate cancer were 42.1% (98/233). When comparing clinically insignificant and significant prostate cancer, there were significant differences in mean age (63.7 vs 65.9, p=0.007), prostate volume (47.1ml vs 42.2ml, p=0.021), PSA density (0.096ng/ml2 vs 0.104 ng/ml2, p=0.03), maximum tumor volume in biopsy core (11.6% vs 18.3%, p<0.001), rate of 2 positive cores (19.3% vs 39.8%, p=0.001). On multivariate analysis, mean age (p=0.022), PSA density (p=0.017), maximum tumor volume (p=0.001) and 2 positive cores (p=0.005) were independent predictive factors for clinically significant prostate cancer. CONCLUSIONS Significant proportion of patients who are candidates for active surveillance had clinically significant prostate cancer. Especially age, PSA density, maximum tumor volume and 2 positive cores were independent significant predictive factors for clinically significant prostate cancer. In performing active surveillance, these findings should be considered. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e276-e277 Peer Review Report Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Seol Ho Choo Seoul, Korea, Republic of More articles by this author Hyun Hwan Sung Seoul, Korea, Republic of More articles by this author Hyeon Jun Jang Seoul, Korea, Republic of More articles by this author Yoon Seok Suh Seoul, Korea, Republic of More articles by this author U Seok Jeong Seoul, Korea, Republic of More articles by this author Wan Song Seoul, Korea, Republic of More articles by this author Ji Young Kim Gyeonggi-do, Korea, Republic of More articles by this author Dong Soo Ryu Changwon, Korea, Republic of More articles by this author Hwang Gyun Jeon Seoul, Korea, Republic of More articles by this author Minki Baek Seoul, Korea, Republic of More articles by this author Byong chang Jeong Seoul, Korea, Republic of More articles by this author Seong Il Seo Seoul, Korea, Republic of More articles by this author Seong Soo Jeon Seoul, Korea, Republic of More articles by this author Han Yong Choi Seoul, Korea, Republic of More articles by this author Hyun Moo Lee Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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