Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021020634> ?p ?o ?g. }
- W2021020634 endingPage "222" @default.
- W2021020634 startingPage "217" @default.
- W2021020634 abstract "Hypertrophic cardiomyopathy (HCM) is a clinically heterogeneous disease, which suggests that a number of factors exist which modify disease outcome. Gender may be one such factor as more males present with the disease compared with females. The aim of the present study was to determine if an association exists between genetic variation in sex hormone receptors and the development of left ventricular hypertrophy in HCM. The study population included 200 unrelated individuals from an Australian HCM cohort. Clinical evaluation was performed. Genetic analysis of the androgen receptor (AR), estrogen receptor 1 (ESR1), estrogen receptor 2 (ESR2), and aromatase (CYP19A1) genes, was carried out in all patients. Fewer (CAG)n repeats within the AR gene were significantly associated with higher maximal left ventricular wall thickness (LVWT) in males (P=0.008), adjusting for age. Male carriers of the A allele at SNP rs6915267, located in the promoter region of ESR1, had an 11% decrease in mean LVWT compared to male GG homozygotes (P=0.047). We report for the first time that variation at the AR gene is associated with left ventricular hypertrophy in males with HCM. Understanding the impact of sex hormones on phenotype will be helpful in the risk stratification and clinical management of HCM patients." @default.
- W2021020634 created "2016-06-24" @default.
- W2021020634 creator A5012202047 @default.
- W2021020634 creator A5013795044 @default.
- W2021020634 creator A5029192188 @default.
- W2021020634 creator A5050750639 @default.
- W2021020634 creator A5060738174 @default.
- W2021020634 creator A5064235722 @default.
- W2021020634 creator A5072395765 @default.
- W2021020634 date "2008-08-01" @default.
- W2021020634 modified "2023-10-15" @default.
- W2021020634 title "Sex hormone receptor gene variation associated with phenotype in male hypertrophic cardiomyopathy patients" @default.
- W2021020634 cites W1982839289 @default.
- W2021020634 cites W1983934627 @default.
- W2021020634 cites W1984486655 @default.
- W2021020634 cites W1988373211 @default.
- W2021020634 cites W1996847743 @default.
- W2021020634 cites W2006862162 @default.
- W2021020634 cites W2007734228 @default.
- W2021020634 cites W2015381694 @default.
- W2021020634 cites W2033320448 @default.
- W2021020634 cites W2034574098 @default.
- W2021020634 cites W2040268049 @default.
- W2021020634 cites W2041042445 @default.
- W2021020634 cites W2041987808 @default.
- W2021020634 cites W2045394907 @default.
- W2021020634 cites W2051450681 @default.
- W2021020634 cites W2062278724 @default.
- W2021020634 cites W2063097062 @default.
- W2021020634 cites W2067121447 @default.
- W2021020634 cites W2071942696 @default.
- W2021020634 cites W2076034570 @default.
- W2021020634 cites W2080018118 @default.
- W2021020634 cites W2084645119 @default.
- W2021020634 cites W2086812402 @default.
- W2021020634 cites W2093953754 @default.
- W2021020634 cites W2097115552 @default.
- W2021020634 cites W2101065984 @default.
- W2021020634 cites W2106866297 @default.
- W2021020634 cites W2131238391 @default.
- W2021020634 cites W2151007116 @default.
- W2021020634 cites W2154753542 @default.
- W2021020634 cites W2157265934 @default.
- W2021020634 cites W2284899510 @default.
- W2021020634 cites W2321185968 @default.
- W2021020634 cites W2325990028 @default.
- W2021020634 cites W4240770017 @default.
- W2021020634 doi "https://doi.org/10.1016/j.yjmcc.2008.05.016" @default.
- W2021020634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18617186" @default.
- W2021020634 hasPublicationYear "2008" @default.
- W2021020634 type Work @default.
- W2021020634 sameAs 2021020634 @default.
- W2021020634 citedByCount "48" @default.
- W2021020634 countsByYear W20210206342012 @default.
- W2021020634 countsByYear W20210206342013 @default.
- W2021020634 countsByYear W20210206342014 @default.
- W2021020634 countsByYear W20210206342015 @default.
- W2021020634 countsByYear W20210206342016 @default.
- W2021020634 countsByYear W20210206342017 @default.
- W2021020634 countsByYear W20210206342018 @default.
- W2021020634 countsByYear W20210206342019 @default.
- W2021020634 countsByYear W20210206342020 @default.
- W2021020634 countsByYear W20210206342021 @default.
- W2021020634 countsByYear W20210206342022 @default.
- W2021020634 countsByYear W20210206342023 @default.
- W2021020634 crossrefType "journal-article" @default.
- W2021020634 hasAuthorship W2021020634A5012202047 @default.
- W2021020634 hasAuthorship W2021020634A5013795044 @default.
- W2021020634 hasAuthorship W2021020634A5029192188 @default.
- W2021020634 hasAuthorship W2021020634A5050750639 @default.
- W2021020634 hasAuthorship W2021020634A5060738174 @default.
- W2021020634 hasAuthorship W2021020634A5064235722 @default.
- W2021020634 hasAuthorship W2021020634A5072395765 @default.
- W2021020634 hasConcept C104317684 @default.
- W2021020634 hasConcept C121608353 @default.
- W2021020634 hasConcept C126322002 @default.
- W2021020634 hasConcept C127716648 @default.
- W2021020634 hasConcept C134018914 @default.
- W2021020634 hasConcept C172313692 @default.
- W2021020634 hasConcept C2776002628 @default.
- W2021020634 hasConcept C2777164284 @default.
- W2021020634 hasConcept C2780185194 @default.
- W2021020634 hasConcept C2780192828 @default.
- W2021020634 hasConcept C2908647359 @default.
- W2021020634 hasConcept C530470458 @default.
- W2021020634 hasConcept C54355233 @default.
- W2021020634 hasConcept C61367390 @default.
- W2021020634 hasConcept C71924100 @default.
- W2021020634 hasConcept C84393581 @default.
- W2021020634 hasConcept C84606932 @default.
- W2021020634 hasConcept C86803240 @default.
- W2021020634 hasConcept C99454951 @default.
- W2021020634 hasConceptScore W2021020634C104317684 @default.
- W2021020634 hasConceptScore W2021020634C121608353 @default.
- W2021020634 hasConceptScore W2021020634C126322002 @default.
- W2021020634 hasConceptScore W2021020634C127716648 @default.
- W2021020634 hasConceptScore W2021020634C134018914 @default.
- W2021020634 hasConceptScore W2021020634C172313692 @default.