FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021022017> ?p ?o ?g. }

• W2021022017 endingPage "420" @default.
• W2021022017 startingPage "413" @default.
• W2021022017 abstract "Recent work has demonstrated a role for Na(+)/Ca(2+) exchange in potentiation of the Ca(2+) entry elicited through the human platelet store-operated channel by controlling a Mn(2+)-impermeable Ca(2+) entry pathway. Here we demonstrate that this involves control over the secretion of dense granules by a Na(+)/Ca(2+) exchanger (NCX) and so autocrine signalling between platelets. NCX inhibition reduced dense granule secretion. The reduction in SOCE elicited by NCX inhibition could be reversed by the addition of uninhibited donor cells, their releasate alone, or exogenous ADP and 5-HT. The use of specific receptor antagonists indicated that ATP, ADP and 5-HT all played a role in NCX-dependent autocrine signalling between platelets following thapsigargin stimulation, by activating Mn(2+)-impermeable Ca(2+) entry pathways. These data provide further insight into the mechanisms underlying the known interrelationship between platelet Ca(2+) signalling and dense granule secretion, and suggest an important role for the NCX in potentiation of platelet activation via dense granule secretion and so autocrine signalling. Our results caution the interpretation of platelet Ca(2+) signalling studies involving pharmacological or other manipulations that do not assess possible effects on NCX activity and dense granule secretion." @default.
• W2021022017 created "2016-06-24" @default.
• W2021022017 creator A5046366404 @default.
• W2021022017 creator A5075722475 @default.
• W2021022017 creator A5076187324 @default.
• W2021022017 date "2009-05-01" @default.
• W2021022017 modified "2023-10-13" @default.
• W2021022017 title "A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets" @default.
• W2021022017 cites W107472485 @default.
• W2021022017 cites W1683450014 @default.
• W2021022017 cites W1868175339 @default.
• W2021022017 cites W1969927282 @default.
• W2021022017 cites W1972301390 @default.
• W2021022017 cites W1973819000 @default.
• W2021022017 cites W1977033664 @default.
• W2021022017 cites W1987900638 @default.
• W2021022017 cites W1988302058 @default.
• W2021022017 cites W1992168784 @default.
• W2021022017 cites W2015166032 @default.
• W2021022017 cites W2027094257 @default.
• W2021022017 cites W2027164618 @default.
• W2021022017 cites W2033577946 @default.
• W2021022017 cites W2039959686 @default.
• W2021022017 cites W2044323142 @default.
• W2021022017 cites W2044373850 @default.
• W2021022017 cites W2054675070 @default.
• W2021022017 cites W2079544245 @default.
• W2021022017 cites W2092249201 @default.
• W2021022017 cites W2150530686 @default.
• W2021022017 cites W2164033349 @default.
• W2021022017 cites W2263383772 @default.
• W2021022017 cites W2340984742 @default.
• W2021022017 cites W4247741685 @default.
• W2021022017 cites W4249375250 @default.
• W2021022017 doi "https://doi.org/10.1016/j.ceca.2009.02.003" @default.
• W2021022017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19285721" @default.
• W2021022017 hasPublicationYear "2009" @default.
• W2021022017 type Work @default.
• W2021022017 sameAs 2021022017 @default.
• W2021022017 citedByCount "34" @default.
• W2021022017 countsByYear W20210220172012 @default.
• W2021022017 countsByYear W20210220172013 @default.
• W2021022017 countsByYear W20210220172015 @default.
• W2021022017 countsByYear W20210220172016 @default.
• W2021022017 countsByYear W20210220172017 @default.
• W2021022017 countsByYear W20210220172018 @default.
• W2021022017 countsByYear W20210220172019 @default.
• W2021022017 countsByYear W20210220172020 @default.
• W2021022017 countsByYear W20210220172022 @default.
• W2021022017 countsByYear W20210220172023 @default.
• W2021022017 crossrefType "journal-article" @default.
• W2021022017 hasAuthorship W2021022017A5046366404 @default.
• W2021022017 hasAuthorship W2021022017A5075722475 @default.
• W2021022017 hasAuthorship W2021022017A5076187324 @default.
• W2021022017 hasConcept C126322002 @default.
• W2021022017 hasConcept C128240485 @default.
• W2021022017 hasConcept C134018914 @default.
• W2021022017 hasConcept C151730666 @default.
• W2021022017 hasConcept C170493617 @default.
• W2021022017 hasConcept C178790620 @default.
• W2021022017 hasConcept C185592680 @default.
• W2021022017 hasConcept C201571599 @default.
• W2021022017 hasConcept C203014093 @default.
• W2021022017 hasConcept C25274449 @default.
• W2021022017 hasConcept C2777146706 @default.
• W2021022017 hasConcept C2781295650 @default.
• W2021022017 hasConcept C28406088 @default.
• W2021022017 hasConcept C3018697912 @default.
• W2021022017 hasConcept C49039625 @default.
• W2021022017 hasConcept C49760210 @default.
• W2021022017 hasConcept C519063684 @default.
• W2021022017 hasConcept C55493867 @default.
• W2021022017 hasConcept C62478195 @default.
• W2021022017 hasConcept C71924100 @default.
• W2021022017 hasConcept C86803240 @default.
• W2021022017 hasConcept C89560881 @default.
• W2021022017 hasConcept C95444343 @default.
• W2021022017 hasConceptScore W2021022017C126322002 @default.
• W2021022017 hasConceptScore W2021022017C128240485 @default.
• W2021022017 hasConceptScore W2021022017C134018914 @default.
• W2021022017 hasConceptScore W2021022017C151730666 @default.
• W2021022017 hasConceptScore W2021022017C170493617 @default.
• W2021022017 hasConceptScore W2021022017C178790620 @default.
• W2021022017 hasConceptScore W2021022017C185592680 @default.
• W2021022017 hasConceptScore W2021022017C201571599 @default.
• W2021022017 hasConceptScore W2021022017C203014093 @default.
• W2021022017 hasConceptScore W2021022017C25274449 @default.
• W2021022017 hasConceptScore W2021022017C2777146706 @default.
• W2021022017 hasConceptScore W2021022017C2781295650 @default.
• W2021022017 hasConceptScore W2021022017C28406088 @default.
• W2021022017 hasConceptScore W2021022017C3018697912 @default.
• W2021022017 hasConceptScore W2021022017C49039625 @default.
• W2021022017 hasConceptScore W2021022017C49760210 @default.
• W2021022017 hasConceptScore W2021022017C519063684 @default.
• W2021022017 hasConceptScore W2021022017C55493867 @default.
• W2021022017 hasConceptScore W2021022017C62478195 @default.
• W2021022017 hasConceptScore W2021022017C71924100 @default.
• W2021022017 hasConceptScore W2021022017C86803240 @default.

• next