Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021024064> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2021024064 endingPage "224" @default.
- W2021024064 startingPage "218" @default.
- W2021024064 abstract "Non-K-region polycyclic aromatic hydrocarbon (PAH) o-quinones represent alternative metabolites of PAH trans-dihydro diol proximate carcinogens. These PAH o-quinones react readily with glutathione and N-acetyl-L-cysteine, and these adducts may be responsible for their detoxication. Reactions between benzo[a]pyrene-7,8-dione and either N-acetyl-L-cysteine or glutathione gave three predominant products which were purified by semipreparative reverse-phase high-pressure liquid chromatography and characterized by homonuclear two-dimensional correlation spectroscopy (COSY). The first product corresponded to a Michael type, 1,4-addition product isolated at the level of quinone oxidation. The second product converted to the first and is a presumptive 1,4-addition product isolated at the level of hydroquinone oxidation. The third product was 7,8-dihydroxybenzo[a]pyrene (a hydroquinone) and was formed as a result of the reductive potential of the thiol. Additional proof for the catechol structure was obtained by its conversion to its diacetate and its identity with authentic 7,8-diacetoxybenzo[a]pyrene. The structures of these adducts and intermediates confirm that thiol addition involves formation of the ketol and rearrangement to give a catechol followed by oxidation to yield the quinone adduct. No evidence was obtained for the formation of either bisphenol or bisglutathionyl adducts. The COSY spectra provide the first complete structure of a benzo[a]pyrenyl-peptide conjugate." @default.
- W2021024064 created "2016-06-24" @default.
- W2021024064 creator A5059737908 @default.
- W2021024064 creator A5091320500 @default.
- W2021024064 date "1992-05-01" @default.
- W2021024064 modified "2023-10-16" @default.
- W2021024064 title "Characterization of mercapturic acid and glutathionyl conjugates of benzo[a]pyrene-7,8-dione by two-dimensional NMR" @default.
- W2021024064 cites W1512158712 @default.
- W2021024064 cites W1534343559 @default.
- W2021024064 cites W1542868541 @default.
- W2021024064 cites W1830010496 @default.
- W2021024064 cites W1881840670 @default.
- W2021024064 cites W1993557939 @default.
- W2021024064 cites W2010528272 @default.
- W2021024064 cites W2016413770 @default.
- W2021024064 cites W2019605110 @default.
- W2021024064 cites W2022485959 @default.
- W2021024064 cites W2033275653 @default.
- W2021024064 cites W2037347707 @default.
- W2021024064 cites W2042882924 @default.
- W2021024064 cites W2060572244 @default.
- W2021024064 cites W2078363670 @default.
- W2021024064 cites W2152113767 @default.
- W2021024064 cites W2162525261 @default.
- W2021024064 cites W2414489209 @default.
- W2021024064 cites W2952722925 @default.
- W2021024064 cites W3005341051 @default.
- W2021024064 doi "https://doi.org/10.1021/bc00015a003" @default.
- W2021024064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1520725" @default.
- W2021024064 hasPublicationYear "1992" @default.
- W2021024064 type Work @default.
- W2021024064 sameAs 2021024064 @default.
- W2021024064 citedByCount "26" @default.
- W2021024064 countsByYear W20210240642012 @default.
- W2021024064 countsByYear W20210240642013 @default.
- W2021024064 countsByYear W20210240642014 @default.
- W2021024064 countsByYear W20210240642015 @default.
- W2021024064 countsByYear W20210240642017 @default.
- W2021024064 countsByYear W20210240642018 @default.
- W2021024064 crossrefType "journal-article" @default.
- W2021024064 hasAuthorship W2021024064A5059737908 @default.
- W2021024064 hasAuthorship W2021024064A5091320500 @default.
- W2021024064 hasConcept C108204754 @default.
- W2021024064 hasConcept C178790620 @default.
- W2021024064 hasConcept C181199279 @default.
- W2021024064 hasConcept C185592680 @default.
- W2021024064 hasConcept C2777538855 @default.
- W2021024064 hasConcept C2777550763 @default.
- W2021024064 hasConcept C2777713698 @default.
- W2021024064 hasConcept C2778951431 @default.
- W2021024064 hasConcept C2779444094 @default.
- W2021024064 hasConcept C2780643102 @default.
- W2021024064 hasConcept C538909803 @default.
- W2021024064 hasConcept C71240020 @default.
- W2021024064 hasConceptScore W2021024064C108204754 @default.
- W2021024064 hasConceptScore W2021024064C178790620 @default.
- W2021024064 hasConceptScore W2021024064C181199279 @default.
- W2021024064 hasConceptScore W2021024064C185592680 @default.
- W2021024064 hasConceptScore W2021024064C2777538855 @default.
- W2021024064 hasConceptScore W2021024064C2777550763 @default.
- W2021024064 hasConceptScore W2021024064C2777713698 @default.
- W2021024064 hasConceptScore W2021024064C2778951431 @default.
- W2021024064 hasConceptScore W2021024064C2779444094 @default.
- W2021024064 hasConceptScore W2021024064C2780643102 @default.
- W2021024064 hasConceptScore W2021024064C538909803 @default.
- W2021024064 hasConceptScore W2021024064C71240020 @default.
- W2021024064 hasIssue "3" @default.
- W2021024064 hasLocation W20210240641 @default.
- W2021024064 hasLocation W20210240642 @default.
- W2021024064 hasOpenAccess W2021024064 @default.
- W2021024064 hasPrimaryLocation W20210240641 @default.
- W2021024064 hasRelatedWork W1970963576 @default.
- W2021024064 hasRelatedWork W1996022521 @default.
- W2021024064 hasRelatedWork W2021024064 @default.
- W2021024064 hasRelatedWork W2037917260 @default.
- W2021024064 hasRelatedWork W2060022123 @default.
- W2021024064 hasRelatedWork W2066659601 @default.
- W2021024064 hasRelatedWork W2067832654 @default.
- W2021024064 hasRelatedWork W2080358430 @default.
- W2021024064 hasRelatedWork W2080414939 @default.
- W2021024064 hasRelatedWork W2089445575 @default.
- W2021024064 hasVolume "3" @default.
- W2021024064 isParatext "false" @default.
- W2021024064 isRetracted "false" @default.
- W2021024064 magId "2021024064" @default.
- W2021024064 workType "article" @default.