Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021030923> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2021030923 endingPage "314" @default.
- W2021030923 startingPage "312" @default.
- W2021030923 abstract "Research has shown that exposure to repeated stress alters acute behavioral and neurochemical responses to drugs of abuse. However, few studies have characterized the longer-term detrimental effects of psychostimulant drugs such as methamphetamine (METH) after exposure to chronic stress. The current study tested whether 10 days of unpredictable stress produced greater striatal dopamine depletions after neurotoxic injections of METH and whether monoamine reuptake blockers protected against stress/METH-induced DA depletion. Male rats were exposed to 10 d of unpredictable stress or weighed daily but not stressed. On day 11, all rats were given 4 injections of 0, 7.5, or 10 mg/kg METH, 1 injection every 2 h, and tissue collected 7 d later. Male rats exposed to unpredictable stress had greater depletions of striatal dopamine tissue content than nonstressed controls injected with METH. In a separate study, rats were treated with vehicle, desipramine (10 mg/kg), or fluoxetine (5 mg/kg) daily during the 10-d stress regimen. These antidepressants did not attenuate the stress-potentiated depletion of striatal dopamine. These findings suggest that chronic unpredictable stress enhances vulnerability of the brain to neurotoxic effects of psychostimulants, but this vulnerability is mediated through mechanisms other than the norepinephrine or serotonin uptake systems." @default.
- W2021030923 created "2016-06-24" @default.
- W2021030923 creator A5018503420 @default.
- W2021030923 creator A5042693752 @default.
- W2021030923 date "2004-12-01" @default.
- W2021030923 modified "2023-09-25" @default.
- W2021030923 title "Effects of Chronic Stress on Methamphetamine-Induced Dopamine Depletions in the Striatum" @default.
- W2021030923 cites W1968449546 @default.
- W2021030923 cites W2001446601 @default.
- W2021030923 cites W2073422014 @default.
- W2021030923 cites W2163320407 @default.
- W2021030923 doi "https://doi.org/10.1196/annals.1314.049" @default.
- W2021030923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15677439" @default.
- W2021030923 hasPublicationYear "2004" @default.
- W2021030923 type Work @default.
- W2021030923 sameAs 2021030923 @default.
- W2021030923 citedByCount "11" @default.
- W2021030923 countsByYear W20210309232013 @default.
- W2021030923 countsByYear W20210309232016 @default.
- W2021030923 countsByYear W20210309232017 @default.
- W2021030923 countsByYear W20210309232019 @default.
- W2021030923 countsByYear W20210309232021 @default.
- W2021030923 crossrefType "journal-article" @default.
- W2021030923 hasAuthorship W2021030923A5018503420 @default.
- W2021030923 hasAuthorship W2021030923A5042693752 @default.
- W2021030923 hasConcept C126322002 @default.
- W2021030923 hasConcept C134018914 @default.
- W2021030923 hasConcept C166940927 @default.
- W2021030923 hasConcept C170493617 @default.
- W2021030923 hasConcept C178790620 @default.
- W2021030923 hasConcept C185592680 @default.
- W2021030923 hasConcept C187714386 @default.
- W2021030923 hasConcept C25876315 @default.
- W2021030923 hasConcept C2775864247 @default.
- W2021030923 hasConcept C2778514916 @default.
- W2021030923 hasConcept C2778654844 @default.
- W2021030923 hasConcept C2779177272 @default.
- W2021030923 hasConcept C2779989194 @default.
- W2021030923 hasConcept C2780114369 @default.
- W2021030923 hasConcept C2780250439 @default.
- W2021030923 hasConcept C2780376393 @default.
- W2021030923 hasConcept C2781161787 @default.
- W2021030923 hasConcept C513476851 @default.
- W2021030923 hasConcept C521977710 @default.
- W2021030923 hasConcept C71924100 @default.
- W2021030923 hasConcept C98274493 @default.
- W2021030923 hasConcept C99631742 @default.
- W2021030923 hasConceptScore W2021030923C126322002 @default.
- W2021030923 hasConceptScore W2021030923C134018914 @default.
- W2021030923 hasConceptScore W2021030923C166940927 @default.
- W2021030923 hasConceptScore W2021030923C170493617 @default.
- W2021030923 hasConceptScore W2021030923C178790620 @default.
- W2021030923 hasConceptScore W2021030923C185592680 @default.
- W2021030923 hasConceptScore W2021030923C187714386 @default.
- W2021030923 hasConceptScore W2021030923C25876315 @default.
- W2021030923 hasConceptScore W2021030923C2775864247 @default.
- W2021030923 hasConceptScore W2021030923C2778514916 @default.
- W2021030923 hasConceptScore W2021030923C2778654844 @default.
- W2021030923 hasConceptScore W2021030923C2779177272 @default.
- W2021030923 hasConceptScore W2021030923C2779989194 @default.
- W2021030923 hasConceptScore W2021030923C2780114369 @default.
- W2021030923 hasConceptScore W2021030923C2780250439 @default.
- W2021030923 hasConceptScore W2021030923C2780376393 @default.
- W2021030923 hasConceptScore W2021030923C2781161787 @default.
- W2021030923 hasConceptScore W2021030923C513476851 @default.
- W2021030923 hasConceptScore W2021030923C521977710 @default.
- W2021030923 hasConceptScore W2021030923C71924100 @default.
- W2021030923 hasConceptScore W2021030923C98274493 @default.
- W2021030923 hasConceptScore W2021030923C99631742 @default.
- W2021030923 hasIssue "1" @default.
- W2021030923 hasLocation W20210309231 @default.
- W2021030923 hasLocation W20210309232 @default.
- W2021030923 hasOpenAccess W2021030923 @default.
- W2021030923 hasPrimaryLocation W20210309231 @default.
- W2021030923 hasRelatedWork W1992117874 @default.
- W2021030923 hasRelatedWork W2021030923 @default.
- W2021030923 hasRelatedWork W2026280142 @default.
- W2021030923 hasRelatedWork W2046870724 @default.
- W2021030923 hasRelatedWork W2063105320 @default.
- W2021030923 hasRelatedWork W2065262984 @default.
- W2021030923 hasRelatedWork W2112684472 @default.
- W2021030923 hasRelatedWork W2143308851 @default.
- W2021030923 hasRelatedWork W2171454471 @default.
- W2021030923 hasRelatedWork W2751740487 @default.
- W2021030923 hasVolume "1032" @default.
- W2021030923 isParatext "false" @default.
- W2021030923 isRetracted "false" @default.
- W2021030923 magId "2021030923" @default.
- W2021030923 workType "article" @default.