FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021034116> ?p ?o ?g. }

• W2021034116 endingPage "2014" @default.
• W2021034116 startingPage "2005" @default.
• W2021034116 abstract "p53 is eliminated from K-Ras-mutated cancer cells through direct interaction with Snail. However, it is not achieved through proteasome-mediated degradation or transcriptional repression. Here we provide evidence that p53, binding with Snail, is exported from a K-Ras-mutated cell through a vesicle transport-like mechanism, independently using a p53-nuclear-exporting mechanism. Although we can detect p53 in culture media, a majority of p53 might be degraded by extracellular proteases. Thus, we can recover the secreted p53 in culture media by the inhibition of protease and endocytosis. In addition, a considerable amount of p53 is endocytosed by neighboring cells. As p53 resorption occurs in a K-Ras-dependent manner, treatment of recombinant p53 is detected in the whole-cell lysate of K-Ras-mutated cells, but not in that of wild-type cells. Using the property of p53, we can deliver the chemical (propidium iodine) into K-Ras mutated cells selectively. In contrast, Snail, a co-secreted protein with p53 in response to oncogenic K-Ras, shows resistance to endocytosis and protease, and results in remaining in the media. Thus, we can detect an autoantibody against Snail in the serum of a human cancer patient. Our finding can be used for a mutant K-Ras-specific anticancer drug delivery system and for the diagnosis of pancreatic, colon and lung cancers." @default.
• W2021034116 created "2016-06-24" @default.
• W2021034116 creator A5008352226 @default.
• W2021034116 creator A5021999034 @default.
• W2021034116 creator A5026078878 @default.
• W2021034116 creator A5032563058 @default.
• W2021034116 creator A5040500346 @default.
• W2021034116 creator A5041859422 @default.
• W2021034116 creator A5044285320 @default.
• W2021034116 creator A5058577911 @default.
• W2021034116 creator A5083282376 @default.
• W2021034116 date "2009-04-06" @default.
• W2021034116 modified "2023-10-16" @default.
• W2021034116 title "p53, secreted by K-Ras–Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker" @default.
• W2021034116 cites W1548025148 @default.
• W2021034116 cites W1880414166 @default.
• W2021034116 cites W1963592300 @default.
• W2021034116 cites W1965822047 @default.
• W2021034116 cites W1976830809 @default.
• W2021034116 cites W1995608940 @default.
• W2021034116 cites W1999258680 @default.
• W2021034116 cites W2000287507 @default.
• W2021034116 cites W2004273407 @default.
• W2021034116 cites W2037376917 @default.
• W2021034116 cites W2043485308 @default.
• W2021034116 cites W2047521557 @default.
• W2021034116 cites W2050389860 @default.
• W2021034116 cites W2051409222 @default.
• W2021034116 cites W2053179670 @default.
• W2021034116 cites W2055920435 @default.
• W2021034116 cites W2057747911 @default.
• W2021034116 cites W2061996263 @default.
• W2021034116 cites W2077297619 @default.
• W2021034116 cites W2077353205 @default.
• W2021034116 cites W2098347937 @default.
• W2021034116 cites W2128787275 @default.
• W2021034116 cites W2136707718 @default.
• W2021034116 cites W2138155367 @default.
• W2021034116 cites W2154799239 @default.
• W2021034116 cites W2163798887 @default.
• W2021034116 doi "https://doi.org/10.1038/onc.2009.67" @default.
• W2021034116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19347028" @default.
• W2021034116 hasPublicationYear "2009" @default.
• W2021034116 type Work @default.
• W2021034116 sameAs 2021034116 @default.
• W2021034116 citedByCount "31" @default.
• W2021034116 countsByYear W20210341162012 @default.
• W2021034116 countsByYear W20210341162013 @default.
• W2021034116 countsByYear W20210341162014 @default.
• W2021034116 countsByYear W20210341162015 @default.
• W2021034116 countsByYear W20210341162016 @default.
• W2021034116 countsByYear W20210341162019 @default.
• W2021034116 countsByYear W20210341162020 @default.
• W2021034116 countsByYear W20210341162021 @default.
• W2021034116 crossrefType "journal-article" @default.
• W2021034116 hasAuthorship W2021034116A5008352226 @default.
• W2021034116 hasAuthorship W2021034116A5021999034 @default.
• W2021034116 hasAuthorship W2021034116A5026078878 @default.
• W2021034116 hasAuthorship W2021034116A5032563058 @default.
• W2021034116 hasAuthorship W2021034116A5040500346 @default.
• W2021034116 hasAuthorship W2021034116A5041859422 @default.
• W2021034116 hasAuthorship W2021034116A5044285320 @default.
• W2021034116 hasAuthorship W2021034116A5058577911 @default.
• W2021034116 hasAuthorship W2021034116A5083282376 @default.
• W2021034116 hasBestOaLocation W20210341161 @default.
• W2021034116 hasConcept C121608353 @default.
• W2021034116 hasConcept C1491633281 @default.
• W2021034116 hasConcept C153911025 @default.
• W2021034116 hasConcept C18903297 @default.
• W2021034116 hasConcept C2779965526 @default.
• W2021034116 hasConcept C28005876 @default.
• W2021034116 hasConcept C502942594 @default.
• W2021034116 hasConcept C54355233 @default.
• W2021034116 hasConcept C55493867 @default.
• W2021034116 hasConcept C81885089 @default.
• W2021034116 hasConcept C86803240 @default.
• W2021034116 hasConcept C95444343 @default.
• W2021034116 hasConcept C96232424 @default.
• W2021034116 hasConceptScore W2021034116C121608353 @default.
• W2021034116 hasConceptScore W2021034116C1491633281 @default.
• W2021034116 hasConceptScore W2021034116C153911025 @default.
• W2021034116 hasConceptScore W2021034116C18903297 @default.
• W2021034116 hasConceptScore W2021034116C2779965526 @default.
• W2021034116 hasConceptScore W2021034116C28005876 @default.
• W2021034116 hasConceptScore W2021034116C502942594 @default.
• W2021034116 hasConceptScore W2021034116C54355233 @default.
• W2021034116 hasConceptScore W2021034116C55493867 @default.
• W2021034116 hasConceptScore W2021034116C81885089 @default.
• W2021034116 hasConceptScore W2021034116C86803240 @default.
• W2021034116 hasConceptScore W2021034116C95444343 @default.
• W2021034116 hasConceptScore W2021034116C96232424 @default.
• W2021034116 hasIssue "19" @default.
• W2021034116 hasLocation W20210341161 @default.
• W2021034116 hasLocation W20210341162 @default.
• W2021034116 hasOpenAccess W2021034116 @default.
• W2021034116 hasPrimaryLocation W20210341161 @default.
• W2021034116 hasRelatedWork W2015523157 @default.
• W2021034116 hasRelatedWork W2026159277 @default.

• next