FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021036849> ?p ?o ?g. }

• W2021036849 endingPage "88" @default.
• W2021036849 startingPage "75" @default.
• W2021036849 abstract "The relationship between induction of glutamine synthetase activity by dexamethasone and binding of the steroid to cytosolic glucocorticoid receptors was examined in sensitive C6 and resistant C6H glial cell cultures. Glutamine synthetase activity increased 3-4-fold when C6 cultures were exposed to 7.6 x 10(-6) M dexamethasone. This inductive response was reversible, dose-dependent (ED50 approximately 2 x 10(-8) M), required de novo protein and RNA synthesis, and was elicited only by glucocorticoid steroids. Progesterone, but not epicortisol, antagonized the dexamethasone-induced enzyme increase. In contrast, only a slight inductive effect was observed in dexamethasone-treated C6H cells. Competitive binding assays demonstrated that specific binding of [3H]-dexamethasone to cytosolic receptors was also dose-dependent. The ED50 was approximately 10(-8) M for both C6 and C6H cells. Scatchard analysis revealed that each C6 cell contained approximately 10,800 receptor sites and that the equilibrium dissociation constant (Kd) was 4.5 x 10(-9) M. Each C6H cell possessed approximately 12,200 sites, and the Kd was 6.7 x 10(-9) M. Unlabeled dexamethasone and cortisol (but not epicortisol) competed effectively with [3H]-dexamethasone for binding to cytosolic receptor sites and nuclear sites of both cell types. These results suggest that induction of glutamine synthetase activity in dexamethasone-treated C6 cells is a glucocorticoid-directed response. Since C6H cells are refractory in this regard but contain functional cytosolic receptors which interact with cell nuclei, the basis for their resistance appears to involve some step beyond these cellular processes." @default.
• W2021036849 created "2016-06-24" @default.
• W2021036849 creator A5038897315 @default.
• W2021036849 creator A5050400980 @default.
• W2021036849 creator A5075645264 @default.
• W2021036849 date "1981-01-01" @default.
• W2021036849 modified "2023-10-16" @default.
• W2021036849 title "Glucocorticoid receptor properties and glucocorticoid regulation of glutamine synthetase activity in sensitive C6 and resistant C6H glial cells" @default.
• W2021036849 cites W1572324846 @default.
• W2021036849 cites W1775749144 @default.
• W2021036849 cites W1977481778 @default.
• W2021036849 cites W1983649348 @default.
• W2021036849 cites W1986150164 @default.
• W2021036849 cites W1987080089 @default.
• W2021036849 cites W1990918868 @default.
• W2021036849 cites W1995186577 @default.
• W2021036849 cites W1997995567 @default.
• W2021036849 cites W1999918168 @default.
• W2021036849 cites W2001568860 @default.
• W2021036849 cites W2019853746 @default.
• W2021036849 cites W2022692782 @default.
• W2021036849 cites W2023222913 @default.
• W2021036849 cites W2049272715 @default.
• W2021036849 cites W2056401491 @default.
• W2021036849 cites W2056514569 @default.
• W2021036849 cites W2057199796 @default.
• W2021036849 cites W2068270931 @default.
• W2021036849 cites W2109118799 @default.
• W2021036849 cites W2293556558 @default.
• W2021036849 cites W2320042400 @default.
• W2021036849 cites W2322349372 @default.
• W2021036849 cites W2332013106 @default.
• W2021036849 cites W2614923698 @default.
• W2021036849 cites W88776677 @default.
• W2021036849 doi "https://doi.org/10.1002/jnr.490060108" @default.
• W2021036849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6111614" @default.
• W2021036849 hasPublicationYear "1981" @default.
• W2021036849 type Work @default.
• W2021036849 sameAs 2021036849 @default.
• W2021036849 citedByCount "21" @default.
• W2021036849 countsByYear W20210368492021 @default.
• W2021036849 crossrefType "journal-article" @default.
• W2021036849 hasAuthorship W2021036849A5038897315 @default.
• W2021036849 hasAuthorship W2021036849A5050400980 @default.
• W2021036849 hasAuthorship W2021036849A5075645264 @default.
• W2021036849 hasConcept C126322002 @default.
• W2021036849 hasConcept C134018914 @default.
• W2021036849 hasConcept C170493617 @default.
• W2021036849 hasConcept C181199279 @default.
• W2021036849 hasConcept C2779289688 @default.
• W2021036849 hasConcept C2779349466 @default.
• W2021036849 hasConcept C2780401358 @default.
• W2021036849 hasConcept C2780841215 @default.
• W2021036849 hasConcept C2780902042 @default.
• W2021036849 hasConcept C42533223 @default.
• W2021036849 hasConcept C515207424 @default.
• W2021036849 hasConcept C54355233 @default.
• W2021036849 hasConcept C55493867 @default.
• W2021036849 hasConcept C59493245 @default.
• W2021036849 hasConcept C71315377 @default.
• W2021036849 hasConcept C71924100 @default.
• W2021036849 hasConcept C74998103 @default.
• W2021036849 hasConcept C81885089 @default.
• W2021036849 hasConcept C86803240 @default.
• W2021036849 hasConcept C98539663 @default.
• W2021036849 hasConceptScore W2021036849C126322002 @default.
• W2021036849 hasConceptScore W2021036849C134018914 @default.
• W2021036849 hasConceptScore W2021036849C170493617 @default.
• W2021036849 hasConceptScore W2021036849C181199279 @default.
• W2021036849 hasConceptScore W2021036849C2779289688 @default.
• W2021036849 hasConceptScore W2021036849C2779349466 @default.
• W2021036849 hasConceptScore W2021036849C2780401358 @default.
• W2021036849 hasConceptScore W2021036849C2780841215 @default.
• W2021036849 hasConceptScore W2021036849C2780902042 @default.
• W2021036849 hasConceptScore W2021036849C42533223 @default.
• W2021036849 hasConceptScore W2021036849C515207424 @default.
• W2021036849 hasConceptScore W2021036849C54355233 @default.
• W2021036849 hasConceptScore W2021036849C55493867 @default.
• W2021036849 hasConceptScore W2021036849C59493245 @default.
• W2021036849 hasConceptScore W2021036849C71315377 @default.
• W2021036849 hasConceptScore W2021036849C71924100 @default.
• W2021036849 hasConceptScore W2021036849C74998103 @default.
• W2021036849 hasConceptScore W2021036849C81885089 @default.
• W2021036849 hasConceptScore W2021036849C86803240 @default.
• W2021036849 hasConceptScore W2021036849C98539663 @default.
• W2021036849 hasIssue "1" @default.
• W2021036849 hasLocation W20210368491 @default.
• W2021036849 hasLocation W20210368492 @default.
• W2021036849 hasOpenAccess W2021036849 @default.
• W2021036849 hasPrimaryLocation W20210368491 @default.
• W2021036849 hasRelatedWork W1964287313 @default.
• W2021036849 hasRelatedWork W1976035881 @default.
• W2021036849 hasRelatedWork W1993404602 @default.
• W2021036849 hasRelatedWork W2008264923 @default.
• W2021036849 hasRelatedWork W2021036849 @default.
• W2021036849 hasRelatedWork W2034583712 @default.
• W2021036849 hasRelatedWork W2054337074 @default.
• W2021036849 hasRelatedWork W2071337848 @default.

• next