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• W2021037385 abstract "Approximately 35-40% of patients with classic infantile Pompe disease treated with enzyme replacement therapy (ERT) develop high, sustained antibody titers against the therapeutic enzyme alglucosidase alfa, which abrogates the treatment efficacy. Induction of antigen-specific immune tolerance would greatly enhance ERT for these patients. Here we show that a short-course treatment with non-depleting anti-CD4 monoclonal antibody successfully induced long-term ERT-specific immune tolerance in Pompe disease mice. Our data suggest an effective adjuvant therapy to ERT." @default.
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• W2021037385 date "2014-01-01" @default.
• W2021037385 modified "2023-09-30" @default.
• W2021037385 title "Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease" @default.
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• W2021037385 doi "https://doi.org/10.1016/j.ymgmr.2014.08.005" @default.
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