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- W2021040254 abstract "The anti-viral drug interferon-alpha (IFN-alpha) is widely-known to induce psychiatric and cognitive effects in patients. Previous work has shown that physical exercise can have a positive effect against brain insult. We investigated the effects of a clinically-comparable treatment regime of IFN-alpha on cognitive function in male Wistar rats and assessed the impact of chronic treadmill running on the deficits generated by IFN-alpha. We found that IFN-alpha induced significant impairments in performance on both spatial novelty and object novelty recognition. Chronic forced exercise did not protect against IFN-alpha-induced learning deficits in reactivity to spatial change, but did restore the capacity for novel object recognition in IFN-alpha-treated animals." @default.
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- W2021040254 date "2008-09-01" @default.
- W2021040254 modified "2023-09-26" @default.
- W2021040254 title "Interferon-α-induced deficits in novel object recognition are rescued by chronic exercise" @default.
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- W2021040254 doi "https://doi.org/10.1016/j.physbeh.2008.05.008" @default.
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