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• W2021041306 abstract "After subcutaneous injection of [ 14 C]glucose in the cat the total 14 C content per gram fresh tissue was relatively high in liver, kidney, blood and brain: lower values were obtained in heart, spleen, lung, skeletal mucle and spinal cord. In all organs examined more than 95 % of the radioactivity present at 22 min after injection was contained in the acid-soluble fraction of the tissue: proteins, lipids and nucleic acids together accounted for only 0.2 to 5 % of the radioactivity. In most organs the 14 C in the acid-soluble fraction was present mainly as [ 14 C]glucose, but in nervous tissues a large part (48 to 74 %) of the 14 C was contained in the free amino acid fraction. The incorporation of 14 C from [ 14 C]glucose into amino acids (counts min -1 g fresh tissue -1 ) in vivo was highest in the cerebral cortex and decreased in the order cerebral cortex > cerebellum > pons and medulla > spinal cord: the incorporation into amino acids was several times greater in the brain than in other organs examined. Values obtained for the heart were intermediate between those for brain and other organs. About 80 % of the 14 C incorporated into amino acids of the cerebral cortex was combined in glutamic and aspartic acids. In liver, spleen, muscle, lung and blood the basic and neutral amino acids accounted for a relatively larger proportion of the radioactivity of the amino acid fraction. The 14 C contained in tricarboxylic acid cycle intermediates accounted for 20 to 32 % of the radioactivity of the acid-soluble fraction in different parts of the brain." @default.
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• W2021041306 date "1964-04-14" @default.
• W2021041306 modified "2023-09-25" @default.
• W2021041306 title "The utilization of glucose in the brain and other organs of the cat" @default.
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• W2021041306 doi "https://doi.org/10.1098/rspb.1964.0031" @default.
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