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- W2021044222 abstract "Abstract The antithrombotic effect of suloctidil, a new antispasmotic with platelet anti-aggregating properties was evaluated in two rabbit models. In the first, thrombi were formed in polyethylene catheters placed in the lumens of the carotid arteries. Quantitation of the thrombi was achieved with radio-labelled fibrinogen. The antithrombotic effect of suloctidil was significantly greater than placebo or aspirin and insignificantly greater than intravenously administered dipyridamole. In the second model, two appropriately spaced doses of endotoxin were given. Suloctidil did not inhibit the initial endotoxin induced consumption of platelets or WBC, but did inhibit the second fall in platelets believed related to thrombin elaboration. An accompanying slight inhibition of fibrin deposition and fibrinogen consumption was found." @default.
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- W2021044222 date "1976-08-01" @default.
- W2021044222 modified "2023-09-25" @default.
- W2021044222 title "Evaluation of antithrombotic properties of suloctidil in comparison with aspirin and dipyridamole" @default.
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- W2021044222 doi "https://doi.org/10.1016/0049-3848(76)90154-7" @default.
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