FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021051084> ?p ?o ?g. }

• W2021051084 endingPage "1240" @default.
• W2021051084 startingPage "1236" @default.
• W2021051084 abstract "The Pseudomonas aeruginosa-derived phenazine pigments pyocyanin and 1-hydroxyphenazine (1-hp) prime human neutrophils for enhanced, stimulus-activated release of superoxide and myeloperoxidase (MPO), respectively. In the present study, the modulatory potentials of the antimicrobial agents clindamycin, erythromycin, and roxithromycin (10 and 20 micrograms/ml) on the prooxidative interactions of pyocyanin and 1-hp (12.5 microM) with human neutrophils have been investigated. Clindamycin, erythromycin, and especially roxithromycin caused dose-related inhibition of the generation of superoxide by both untreated and pyocyanin-treated neutrophils during activation with either the synthetic chemotactic tripeptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) or the calcium ionophore A23187. The antimicrobial agents also inhibited the generation of reactive oxidants by the MPO-H2O2-halide system during activation of both untreated and 1-hp-treated neutrophils by FMLP. These effects appeared to be due to drug-related interference with membrane-associated oxidative metabolism, since none of the antimicrobial agents inhibited the release of MPO by activated neutrophils, nor did they possess oxidant-scavenging properties. These data demonstrate that clindamycin, erythromycin, and especially roxithromycin antagonize the proinflammatory interactions of pyocyanin and 1-hp with neutrophils and indicate a possible therapeutic role for these antimicrobial agents in the prevention of tissue damage in diseases characterized by P. aeruginosa infection." @default.
• W2021051084 created "2016-06-24" @default.
• W2021051084 creator A5000858122 @default.
• W2021051084 creator A5030988903 @default.
• W2021051084 creator A5033785127 @default.
• W2021051084 creator A5034466911 @default.
• W2021051084 creator A5044675864 @default.
• W2021051084 creator A5048649227 @default.
• W2021051084 creator A5050333890 @default.
• W2021051084 creator A5056053442 @default.
• W2021051084 creator A5077845525 @default.
• W2021051084 creator A5090905088 @default.
• W2021051084 date "1992-06-01" @default.
• W2021051084 modified "2023-09-26" @default.
• W2021051084 title "Clindamycin, erythromycin, and roxithromycin inhibit the proinflammatory interactions of Pseudomonas aeruginosa pigments with human neutrophils in vitro" @default.
• W2021051084 cites W1943184335 @default.
• W2021051084 cites W1968135282 @default.
• W2021051084 cites W1982857351 @default.
• W2021051084 cites W2006669294 @default.
• W2021051084 cites W2006845738 @default.
• W2021051084 cites W2018744199 @default.
• W2021051084 cites W2026606228 @default.
• W2021051084 cites W2034894214 @default.
• W2021051084 cites W2044597798 @default.
• W2021051084 cites W2046531916 @default.
• W2021051084 cites W2046931672 @default.
• W2021051084 cites W2055538893 @default.
• W2021051084 cites W2059678185 @default.
• W2021051084 cites W2061965039 @default.
• W2021051084 cites W2072876551 @default.
• W2021051084 cites W2073296724 @default.
• W2021051084 cites W2075801503 @default.
• W2021051084 cites W2078197789 @default.
• W2021051084 cites W2078567081 @default.
• W2021051084 cites W2084584756 @default.
• W2021051084 cites W2092761438 @default.
• W2021051084 cites W2097826031 @default.
• W2021051084 cites W2107064676 @default.
• W2021051084 cites W2117966002 @default.
• W2021051084 cites W2125006392 @default.
• W2021051084 cites W2131270278 @default.
• W2021051084 cites W2166913564 @default.
• W2021051084 cites W2169117767 @default.
• W2021051084 cites W3035322935 @default.
• W2021051084 cites W4241824092 @default.
• W2021051084 doi "https://doi.org/10.1128/aac.36.6.1236" @default.
• W2021051084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/190324" @default.
• W2021051084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1329616" @default.
• W2021051084 hasPublicationYear "1992" @default.
• W2021051084 type Work @default.
• W2021051084 sameAs 2021051084 @default.
• W2021051084 citedByCount "19" @default.
• W2021051084 countsByYear W20210510842020 @default.
• W2021051084 countsByYear W20210510842022 @default.
• W2021051084 crossrefType "journal-article" @default.
• W2021051084 hasAuthorship W2021051084A5000858122 @default.
• W2021051084 hasAuthorship W2021051084A5030988903 @default.
• W2021051084 hasAuthorship W2021051084A5033785127 @default.
• W2021051084 hasAuthorship W2021051084A5034466911 @default.
• W2021051084 hasAuthorship W2021051084A5044675864 @default.
• W2021051084 hasAuthorship W2021051084A5048649227 @default.
• W2021051084 hasAuthorship W2021051084A5050333890 @default.
• W2021051084 hasAuthorship W2021051084A5056053442 @default.
• W2021051084 hasAuthorship W2021051084A5077845525 @default.
• W2021051084 hasAuthorship W2021051084A5090905088 @default.
• W2021051084 hasBestOaLocation W20210510842 @default.
• W2021051084 hasConcept C104317684 @default.
• W2021051084 hasConcept C118687296 @default.
• W2021051084 hasConcept C164027704 @default.
• W2021051084 hasConcept C181199279 @default.
• W2021051084 hasConcept C185592680 @default.
• W2021051084 hasConcept C203014093 @default.
• W2021051084 hasConcept C2776914184 @default.
• W2021051084 hasConcept C2777458120 @default.
• W2021051084 hasConcept C2777637488 @default.
• W2021051084 hasConcept C2778423520 @default.
• W2021051084 hasConcept C2780206985 @default.
• W2021051084 hasConcept C2780795997 @default.
• W2021051084 hasConcept C2781427627 @default.
• W2021051084 hasConcept C4937899 @default.
• W2021051084 hasConcept C501593827 @default.
• W2021051084 hasConcept C523546767 @default.
• W2021051084 hasConcept C54355233 @default.
• W2021051084 hasConcept C55493867 @default.
• W2021051084 hasConcept C60987743 @default.
• W2021051084 hasConcept C86803240 @default.
• W2021051084 hasConcept C89423630 @default.
• W2021051084 hasConcept C98274493 @default.
• W2021051084 hasConceptScore W2021051084C104317684 @default.
• W2021051084 hasConceptScore W2021051084C118687296 @default.
• W2021051084 hasConceptScore W2021051084C164027704 @default.
• W2021051084 hasConceptScore W2021051084C181199279 @default.
• W2021051084 hasConceptScore W2021051084C185592680 @default.
• W2021051084 hasConceptScore W2021051084C203014093 @default.
• W2021051084 hasConceptScore W2021051084C2776914184 @default.
• W2021051084 hasConceptScore W2021051084C2777458120 @default.
• W2021051084 hasConceptScore W2021051084C2777637488 @default.
• W2021051084 hasConceptScore W2021051084C2778423520 @default.

• next