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- W2021056331 abstract "In the cerebellar circuit, Golgi cells are thought to contribute to information processing and integration via feedback mechanisms. In these mechanisms, dynamic modulation of Golgi cell excitability is necessary because GABA from Golgi cells causes tonic inhibition on granule cells. We studied the role and synaptic mechanisms of postsynaptic metabotropic glutamate receptor subtype 2 (mGluR2) at granule cell-Golgi cell synapses, using whole-cell recording of green fluorescent protein-positive Golgi cells of wild-type and mGluR2-deficient mice. Postsynaptic mGluR2 was activated by glutamate from granule cells and hyperpolarized Golgi cells via G protein-coupled inwardly rectifying K+ channels (GIRKs). This hyperpolarization conferred long-lasting silencing of Golgi cells, the duration and extents of which were dependent on stimulus strengths. Postsynaptic mGluR2 thus senses inputs from granule cells and is most likely important for spatiotemporal modulation of mossy fiber-granule cell transmission before distributing inputs to Purkinje cells." @default.
- W2021056331 created "2016-06-24" @default.
- W2021056331 creator A5045763682 @default.
- W2021056331 creator A5076242895 @default.
- W2021056331 date "2003-08-01" @default.
- W2021056331 modified "2023-10-18" @default.
- W2021056331 title "mGluR2 Postsynaptically Senses Granule Cell Inputs at Golgi Cell Synapses" @default.
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- W2021056331 doi "https://doi.org/10.1016/s0896-6273(03)00530-0" @default.
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