FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021059897> ?p ?o ?g. }

• W2021059897 endingPage "193" @default.
• W2021059897 startingPage "189" @default.
• W2021059897 abstract "In recent years, it has become quite evident that numerous proteins exist as an ensemble of conformers that collectively appears to be intrinsically disordered (ID). Of particular significance is the growing body of evidence that intrinsic disorder is found in disproportionately higher amounts in cell signaling proteins and transcription factors, suggesting an important role in their regulatory capacity. Since these proteins are known to possess specific regions/domains that interact with specific coregulatory proteins for their efficient functioning, the large flexible regions in this class of proteins may have an advantage over fully folded proteins that can allow them to make more efficient physical functional interactions with their target partners, which may represent a mechanism for regulation of cellular processes. In fact, recent studies from several laboratories have reported existence of ID sequences in such regions in signaling proteins that play a critical role in regulating their functions. There are reports showing that ID regions/domains commonly exist within proteins with modular structures such as transcription factors, and are often located in their transactivation domain. Therefore, it is important to find out their existence and functional roles in transcriptional regulations by transcription factors. In recent years there has been growing evidence suggesting that an induced fit process leads to imposition of folded functional structure in these ID protein regions/domains. In most cases such binding and folding events have been found to occur when ID region encounters its specific binding partner(s)." @default.
• W2021059897 created "2016-06-24" @default.
• W2021059897 creator A5007780827 @default.
• W2021059897 creator A5024489453 @default.
• W2021059897 creator A5045348217 @default.
• W2021059897 date "2009-02-01" @default.
• W2021059897 modified "2023-10-15" @default.
• W2021059897 title "Role of intrinsically disordered protein regions/domains in transcriptional regulation" @default.
• W2021059897 cites W121768123 @default.
• W2021059897 cites W1560584394 @default.
• W2021059897 cites W1963823250 @default.
• W2021059897 cites W1967203779 @default.
• W2021059897 cites W1967700202 @default.
• W2021059897 cites W1975121208 @default.
• W2021059897 cites W1975271726 @default.
• W2021059897 cites W1979266919 @default.
• W2021059897 cites W1981516673 @default.
• W2021059897 cites W1985921281 @default.
• W2021059897 cites W1989880445 @default.
• W2021059897 cites W1990323031 @default.
• W2021059897 cites W1993294667 @default.
• W2021059897 cites W1994151152 @default.
• W2021059897 cites W2002050200 @default.
• W2021059897 cites W2003022823 @default.
• W2021059897 cites W2003561135 @default.
• W2021059897 cites W2006192061 @default.
• W2021059897 cites W2007016963 @default.
• W2021059897 cites W2009455776 @default.
• W2021059897 cites W2010764705 @default.
• W2021059897 cites W2011983814 @default.
• W2021059897 cites W2013593586 @default.
• W2021059897 cites W2015606278 @default.
• W2021059897 cites W2015737242 @default.
• W2021059897 cites W2016170088 @default.
• W2021059897 cites W2020845378 @default.
• W2021059897 cites W2021632119 @default.
• W2021059897 cites W2027035874 @default.
• W2021059897 cites W2029988455 @default.
• W2021059897 cites W2030776726 @default.
• W2021059897 cites W2032311486 @default.
• W2021059897 cites W2033782813 @default.
• W2021059897 cites W2034299708 @default.
• W2021059897 cites W2034718152 @default.
• W2021059897 cites W2037579912 @default.
• W2021059897 cites W2044915892 @default.
• W2021059897 cites W2046745425 @default.
• W2021059897 cites W2049734794 @default.
• W2021059897 cites W2052606462 @default.
• W2021059897 cites W2052757849 @default.
• W2021059897 cites W2054715902 @default.
• W2021059897 cites W2055827177 @default.
• W2021059897 cites W2058674503 @default.
• W2021059897 cites W2060723204 @default.
• W2021059897 cites W2060815747 @default.
• W2021059897 cites W2071125128 @default.
• W2021059897 cites W2073745520 @default.
• W2021059897 cites W2073831251 @default.
• W2021059897 cites W2092153867 @default.
• W2021059897 cites W2094600324 @default.
• W2021059897 cites W2096409300 @default.
• W2021059897 cites W2101953406 @default.
• W2021059897 cites W2102025585 @default.
• W2021059897 cites W2102827103 @default.
• W2021059897 cites W2103743266 @default.
• W2021059897 cites W2110128290 @default.
• W2021059897 cites W2110790611 @default.
• W2021059897 cites W2114823344 @default.
• W2021059897 cites W2119693327 @default.
• W2021059897 cites W2120881407 @default.
• W2021059897 cites W2121905499 @default.
• W2021059897 cites W2126303237 @default.
• W2021059897 cites W2131144673 @default.
• W2021059897 cites W2132554625 @default.
• W2021059897 cites W2149472608 @default.
• W2021059897 cites W2149573413 @default.
• W2021059897 cites W2150228320 @default.
• W2021059897 cites W2162720882 @default.
• W2021059897 cites W2163610346 @default.
• W2021059897 cites W2172712627 @default.
• W2021059897 cites W2614130212 @default.
• W2021059897 cites W4210968583 @default.
• W2021059897 doi "https://doi.org/10.1016/j.lfs.2008.12.002" @default.
• W2021059897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19109982" @default.
• W2021059897 hasPublicationYear "2009" @default.
• W2021059897 type Work @default.
• W2021059897 sameAs 2021059897 @default.
• W2021059897 citedByCount "70" @default.
• W2021059897 countsByYear W20210598972012 @default.
• W2021059897 countsByYear W20210598972013 @default.
• W2021059897 countsByYear W20210598972014 @default.
• W2021059897 countsByYear W20210598972015 @default.
• W2021059897 countsByYear W20210598972016 @default.
• W2021059897 countsByYear W20210598972017 @default.
• W2021059897 countsByYear W20210598972018 @default.
• W2021059897 countsByYear W20210598972019 @default.
• W2021059897 countsByYear W20210598972020 @default.
• W2021059897 countsByYear W20210598972021 @default.
• W2021059897 countsByYear W20210598972022 @default.

• next