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- W2021068575 abstract "Chlamydophila (Chlamydia) pneumoniae, a gram-negative obligate intracellular bacterium, is a widespread respiratory pathogen. Chronic C. pneumoniae infection has been suggested as a trigger/promoter of inflammation that may result in vascular lesions. Although the genome of C. pneumoniae has been sequenced completely this information has not yet led to an understanding of the mechanisms of acute infection and target cell activation nor to the identification of potential chlamydial virulence factors. Intriguingly, current antibiotic treatment options for acute chlamydial infection were proven to be ineffective with respect to clinical outcome in different groups of atherosclerotic patients. The reason might be that primary infection of vascular smooth muscle cells and blood monocytes with C. pneumoniae resembles rather a persistent, antibiotic-resistant, than an active infection. In this review we will focus on the importance of putative host cell receptors for C. pneumoniae and subsequently activated signal transduction pathways." @default.
- W2021068575 created "2016-06-24" @default.
- W2021068575 creator A5020143301 @default.
- W2021068575 creator A5040973193 @default.
- W2021068575 creator A5065751866 @default.
- W2021068575 creator A5066509179 @default.
- W2021068575 date "2005-01-01" @default.
- W2021068575 modified "2023-10-13" @default.
- W2021068575 title "Chlamydophila pneumoniae" @default.
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