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- W2021071251 abstract "l-Glutamine is required for the synthesis of complex carbohydrates required for the intercellular adhesion of mouse teratoma cells. It remained to be seen if these pathways were of general importance in the adhesion of other cell types. In this study, using an electronic particle counter assay to measure cell adhesion, Ehrlich ascites, Sarcoma 180 and Taper liver ascites tumor cells require exogenous l-glutamine to aggregate. This effect is concentration dependent and the amino sugar, d-glucosamine, replaces the glutamine requirement. Structural analogs of the active compounds are substantially less effective and metabolic inhibitors block the activity of the effective compounds. Two specific glutamine antagonists, DON (6-diazo-5-oxo-l-norleucine) and azaserine (O-diazoacetyl-serine) decrease the action of l-glutamine but not of d-glucosamine. Trypsin dissociated six day old chick embryo neural retina cells do not require l-glutamine to reaggregate, though the rate of aggregation is enhanced after preincubation with glutamine. Dissociation of small clumps of neural retina and inhibition of reaggregation of these cells are facilitated by preincubation with azaserine for 3–5 h. l-Glutamine reduces the effect of azaserine on retina cells. These results are consistent with known metabolic pathways and suggest that l-glutamine is involved in the synthesis of complex carbohydrates necessary for adhesion in a variety of cell types. The defective adhesion of the tumor cells examined may result from inability to produce glutamine synthetase, or effectively store cr transport l-glutamine." @default.
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- W2021071251 date "1973-03-01" @default.
- W2021071251 modified "2023-09-24" @default.
- W2021071251 title "Utilization of l-glutamine in intercellular adhesion: Ascites tumor and embryonic cells" @default.
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- W2021071251 doi "https://doi.org/10.1016/0014-4827(73)90566-1" @default.
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