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- W2021073574 abstract "The effect of melittin on cytosolic free Ca 2+ concentration ([Ca 2+ ] i ) and viability is largely unknown. This study examined whether melittin alters Ca 2+ levels and causes Ca 2+ -dependent cell death in Madin-Darby canine kidney (MDCK) cells. [Ca 2+ ] i and cell death were measured using the fluorescent dyes fura-2 and WST-1 respectively. Melittin at concentrations above 0.5 μM increased [Ca 2+ ] i in a concentration-dependent manner. The Ca 2+ signal was reduced by 75% by removing extracellular Ca 2+ . The melittin-induced Ca 2+ influx was also implicated by melittin-caused Mn 2+ influx. After pretreatment with 1 μM thapsigargin (an endoplasmic reticulum Ca 2+ pump inhibitor), melittin-induced Ca 2+ release was inhibited; and conversely, melittin pretreatment abolished thapsigargin-induced Ca 2+ release. At concentrations of 0.5–20 μM, melittin killed cells in a concentration-dependent manner. The cytotoxic effect of 0.5 μM melittin was nearly completely reversed by prechelating cytosolic Ca 2+ with BAPTA. Melittin at 0.5–2 μM caused apoptosis as assessed by flow cytometry of propidium iodide staining. Collectively, in MDCK cells, melittin induced a [Ca 2+ ] i rise by causing Ca 2+ release from endoplasmic reticulum and Ca 2+ influx from extracellular space. Furthermore, melittin can cause Ca 2+ -dependent cytotoxicity in a concentration-dependent manner." @default.
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- W2021073574 date "2008-05-01" @default.
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- W2021073574 title "Melittin-induced [Ca2+]i increases and subsequent death in canine renal tubular cells" @default.
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- W2021073574 doi "https://doi.org/10.1177/0960327108094606" @default.
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