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- W2021073734 abstract "Abstract Antisera prepared in rabbits against 4-Monochlorobiphenyl and 3,4,3′,4′-Tetrachlorobiphenyl were used to alter the tissue distribution of these environmental pollutants in the mouse. Mice were passively immunized with rabbit antisera following the absorption and distribution of the substituted biphenyls. Immunization caused in vivo redistribution of the compounds into the vascular space. Tissue/blood concentration ratios were greater in the control than in the antiserum treated animals. Changes intissue/blood ratios were similar to the serum/ antiserum ratios as determined by equilibrium dialysis experiments. These results indicate that it is possible to remove chlorinated biphenyls from tissue stores using specific antisera. Second, the partition of compounds between control serum and specific antiserum may be useful as a prospective screen to detect antisera with sufficient antigen affinity for tissue redistribution studies." @default.
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- W2021073734 date "1979-01-01" @default.
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- W2021073734 title "Effect of specific antisera on the redistribution of chlorinated biphenyls in the mouse" @default.
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- W2021073734 doi "https://doi.org/10.1016/0024-3205(79)90127-9" @default.
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