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- W2021084057 abstract "We studied the effect of cannabinoids on the activity of N-methyl-d-aspartate (NMDA) receptors in the locus coeruleus from rat brain slices by single-unit extracellular recordings. As expected, NMDA (100 μM) strongly excited (by nine fold) the cell firing activity of the locus coeruleus. Perfusion with the endocannabinoid anandamide (1 and 10 μM) or the anandamide transport inhibitor AM 404 (30 μM) enhanced the NMDA-induced excitation of locus coeruleus neurons. Similarly, the synthetic agonists R(+)-WIN 55212-2 (10 μM) and CP 55940 (30 μM) enhanced the effect of NMDA. In the presence of the CB1 receptor antagonists SR 141716A (1 μM) or AM 251 (1 μM), the enhancement induced by anandamide (10 μM) was blocked. Our results suggest that cannabinoids modulate the activity of NMDA receptors in the locus coeruleus through CB1 receptors." @default.
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- W2021084057 date "2004-06-01" @default.
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- W2021084057 title "Cannabinoids enhance N-methyl-d-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices" @default.
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- W2021084057 doi "https://doi.org/10.1016/j.neulet.2004.02.073" @default.
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