FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021084073> ?p ?o ?g. }

• W2021084073 endingPage "390" @default.
• W2021084073 startingPage "383" @default.
• W2021084073 abstract "The present study investigated polysomnographically assessed sleep parameters in alcohol-dependent patients after withdrawal and in healthy control subjects during baseline and after a cholinergic stimulation paradigm. The aim of the study was to test whether sleep parameters, especially rapid eye movement (REM) sleep variables, may serve as predictors for relapse in alcohol-dependent patients.Forty patients diagnosed with alcohol dependence were admitted to a specialized ward for alcohol withdrawal and were investigated by polysomnography at three time points: 2-3 weeks after withdrawal (T0) and at follow-up investigations 6 (T1) and 12 (T2) months after discharge from the hospital. A subgroup of patients (n = 17) was studied at T0 after challenge with galanthamine, a reversible cholinesterase inhibitor (cholinergic REM induction test, CRIT). Patients were compared with two control groups: a) 30 healthy control subjects (matched for age- and gender-distribution) for comparison at baseline conditions; and b) 17 age- and gender-matched control subjects for comparison with the CRIT.At baseline the patients showed significant disturbances of sleep continuity and sleep architecture (decreased slow-wave sleep, SWS) and exhibited an increase of REM sleep pressure (a combined index of REM latency, REM density, and REM sleep percent). Galanthamine provoked significant alterations of sleep continuity, sleep architecture (reduced SWS), and increased most of the components of REM pressure, taking patients and control subjects together. Apart from SWS %SPT (sleep period time) no significant drug-group interactions occurred. Patients who remained abstinent (n = 11) for at least 6 months at follow-up exhibited significantly less abnormalities of REM sleep at T0 compared to the group of patients that relapsed at 6 months follow-up.It is concluded that increased REM sleep pressure after alcohol withdrawal is a robust predictor of vulnerability to relapse. Thus, a subgroup of alcoholic patients appears to exhibit distinct neurobiological abnormalities assessable by polysomnography that are related to an increased vulnerability for alcoholism and early relapse." @default.
• W2021084073 created "2016-06-24" @default.
• W2021084073 creator A5000392630 @default.
• W2021084073 creator A5021106262 @default.
• W2021084073 creator A5036191731 @default.
• W2021084073 creator A5084103544 @default.
• W2021084073 creator A5084930489 @default.
• W2021084073 creator A5089061105 @default.
• W2021084073 date "2001-09-01" @default.
• W2021084073 modified "2023-09-27" @default.
• W2021084073 title "Sleep and the cholinergic rapid eye movement sleep induction test in patients with primary alcohol dependence" @default.
• W2021084073 cites W2004530307 @default.
• W2021084073 cites W2006919925 @default.
• W2021084073 cites W2014585244 @default.
• W2021084073 cites W2020863462 @default.
• W2021084073 cites W2022140959 @default.
• W2021084073 cites W2045042247 @default.
• W2021084073 cites W2053899378 @default.
• W2021084073 cites W2055930578 @default.
• W2021084073 cites W2056607297 @default.
• W2021084073 cites W2061914600 @default.
• W2021084073 cites W2065205960 @default.
• W2021084073 cites W2085089038 @default.
• W2021084073 cites W2086064751 @default.
• W2021084073 cites W2088007780 @default.
• W2021084073 cites W2090480324 @default.
• W2021084073 cites W2093337952 @default.
• W2021084073 cites W2123688023 @default.
• W2021084073 cites W2126683149 @default.
• W2021084073 cites W2138042798 @default.
• W2021084073 cites W2151487996 @default.
• W2021084073 cites W2165468367 @default.
• W2021084073 cites W2417398028 @default.
• W2021084073 doi "https://doi.org/10.1016/s0006-3223(01)01172-6" @default.
• W2021084073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11543743" @default.
• W2021084073 hasPublicationYear "2001" @default.
• W2021084073 type Work @default.
• W2021084073 sameAs 2021084073 @default.
• W2021084073 citedByCount "67" @default.
• W2021084073 countsByYear W20210840732012 @default.
• W2021084073 countsByYear W20210840732013 @default.
• W2021084073 countsByYear W20210840732014 @default.
• W2021084073 countsByYear W20210840732015 @default.
• W2021084073 countsByYear W20210840732016 @default.
• W2021084073 countsByYear W20210840732017 @default.
• W2021084073 countsByYear W20210840732018 @default.
• W2021084073 countsByYear W20210840732019 @default.
• W2021084073 countsByYear W20210840732020 @default.
• W2021084073 countsByYear W20210840732021 @default.
• W2021084073 countsByYear W20210840732022 @default.
• W2021084073 countsByYear W20210840732023 @default.
• W2021084073 crossrefType "journal-article" @default.
• W2021084073 hasAuthorship W2021084073A5000392630 @default.
• W2021084073 hasAuthorship W2021084073A5021106262 @default.
• W2021084073 hasAuthorship W2021084073A5036191731 @default.
• W2021084073 hasAuthorship W2021084073A5084103544 @default.
• W2021084073 hasAuthorship W2021084073A5084930489 @default.
• W2021084073 hasAuthorship W2021084073A5089061105 @default.
• W2021084073 hasConcept C110539466 @default.
• W2021084073 hasConcept C111919701 @default.
• W2021084073 hasConcept C118552586 @default.
• W2021084073 hasConcept C126322002 @default.
• W2021084073 hasConcept C153050134 @default.
• W2021084073 hasConcept C15744967 @default.
• W2021084073 hasConcept C169760540 @default.
• W2021084073 hasConcept C22885893 @default.
• W2021084073 hasConcept C2775841894 @default.
• W2021084073 hasConcept C2778205975 @default.
• W2021084073 hasConcept C2779213384 @default.
• W2021084073 hasConcept C41008148 @default.
• W2021084073 hasConcept C42219234 @default.
• W2021084073 hasConcept C522805319 @default.
• W2021084073 hasConcept C548259974 @default.
• W2021084073 hasConcept C71924100 @default.
• W2021084073 hasConceptScore W2021084073C110539466 @default.
• W2021084073 hasConceptScore W2021084073C111919701 @default.
• W2021084073 hasConceptScore W2021084073C118552586 @default.
• W2021084073 hasConceptScore W2021084073C126322002 @default.
• W2021084073 hasConceptScore W2021084073C153050134 @default.
• W2021084073 hasConceptScore W2021084073C15744967 @default.
• W2021084073 hasConceptScore W2021084073C169760540 @default.
• W2021084073 hasConceptScore W2021084073C22885893 @default.
• W2021084073 hasConceptScore W2021084073C2775841894 @default.
• W2021084073 hasConceptScore W2021084073C2778205975 @default.
• W2021084073 hasConceptScore W2021084073C2779213384 @default.
• W2021084073 hasConceptScore W2021084073C41008148 @default.
• W2021084073 hasConceptScore W2021084073C42219234 @default.
• W2021084073 hasConceptScore W2021084073C522805319 @default.
• W2021084073 hasConceptScore W2021084073C548259974 @default.
• W2021084073 hasConceptScore W2021084073C71924100 @default.
• W2021084073 hasIssue "5" @default.
• W2021084073 hasLocation W20210840731 @default.
• W2021084073 hasLocation W20210840732 @default.
• W2021084073 hasOpenAccess W2021084073 @default.
• W2021084073 hasPrimaryLocation W20210840731 @default.
• W2021084073 hasRelatedWork W1989142763 @default.
• W2021084073 hasRelatedWork W2013730087 @default.
• W2021084073 hasRelatedWork W2048103137 @default.

• next