Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021084899> ?p ?o ?g. }
- W2021084899 endingPage "744" @default.
- W2021084899 startingPage "733" @default.
- W2021084899 abstract "Susceptibility to infection with Cryptococcus neoformans is tightly determined by production of IL-4. In this study, we investigated the time course of IL-4 production and its innate cellular source in mice infected intranasally with C. neoformans. We show that pulmonary IL-4 production starts surprisingly late after 6 weeks of infection. Interestingly, in the lungs of infected mice, pulmonary T helper (Th) cells and eosinophils produce significant amounts of IL-4. In eosinophil-deficient ΔdblGATA mice, IL-33 receptor-expressing Th2s are significantly reduced, albeit not absent, whereas protective Th1 and Th17 responses are enhanced. In addition, recruitment of pulmonary inflammatory cells during infection with C. neoformans is reduced in the absence of eosinophils. These data expand previous findings emphasizing an exclusively destructive effector function by eosinophilic granulocytes. Moreover, in ΔdblGATA mice, fungal control is slightly enhanced in the lung; however, dissemination of Cryptococcus is not prevented. Therefore, eosinophils play an immunoregulatory role that contributes to Th2-dependent susceptibility in allergic inflammation during bronchopulmonary mycosis." @default.
- W2021084899 created "2016-06-24" @default.
- W2021084899 creator A5000536993 @default.
- W2021084899 creator A5004324305 @default.
- W2021084899 creator A5010798008 @default.
- W2021084899 creator A5027261987 @default.
- W2021084899 creator A5041692285 @default.
- W2021084899 creator A5043555316 @default.
- W2021084899 creator A5059035521 @default.
- W2021084899 creator A5059769491 @default.
- W2021084899 creator A5068754475 @default.
- W2021084899 creator A5072825908 @default.
- W2021084899 date "2011-08-01" @default.
- W2021084899 modified "2023-10-12" @default.
- W2021084899 title "Eosinophils Contribute to IL-4 Production and Shape the T-Helper Cytokine Profile and Inflammatory Response in Pulmonary Cryptococcosis" @default.
- W2021084899 cites W1501602460 @default.
- W2021084899 cites W1518310332 @default.
- W2021084899 cites W1539825474 @default.
- W2021084899 cites W1543145942 @default.
- W2021084899 cites W1543271400 @default.
- W2021084899 cites W1545960442 @default.
- W2021084899 cites W1585461212 @default.
- W2021084899 cites W1621505595 @default.
- W2021084899 cites W1650320961 @default.
- W2021084899 cites W1822074961 @default.
- W2021084899 cites W1843956515 @default.
- W2021084899 cites W1885649436 @default.
- W2021084899 cites W1926391481 @default.
- W2021084899 cites W1941277890 @default.
- W2021084899 cites W1965580171 @default.
- W2021084899 cites W1965734808 @default.
- W2021084899 cites W1970511844 @default.
- W2021084899 cites W1971888466 @default.
- W2021084899 cites W1972993283 @default.
- W2021084899 cites W1987746874 @default.
- W2021084899 cites W1995420341 @default.
- W2021084899 cites W2005246059 @default.
- W2021084899 cites W2011777173 @default.
- W2021084899 cites W2012514566 @default.
- W2021084899 cites W2014613245 @default.
- W2021084899 cites W2024248233 @default.
- W2021084899 cites W2034021295 @default.
- W2021084899 cites W2038894130 @default.
- W2021084899 cites W2040386323 @default.
- W2021084899 cites W2041889518 @default.
- W2021084899 cites W2045217585 @default.
- W2021084899 cites W2054770913 @default.
- W2021084899 cites W2067500883 @default.
- W2021084899 cites W2068790641 @default.
- W2021084899 cites W2068924629 @default.
- W2021084899 cites W2071879721 @default.
- W2021084899 cites W2072628757 @default.
- W2021084899 cites W2079118227 @default.
- W2021084899 cites W2079203244 @default.
- W2021084899 cites W2079513681 @default.
- W2021084899 cites W2087234685 @default.
- W2021084899 cites W2095601290 @default.
- W2021084899 cites W2099039056 @default.
- W2021084899 cites W2100317350 @default.
- W2021084899 cites W2100791046 @default.
- W2021084899 cites W2101664092 @default.
- W2021084899 cites W2105439894 @default.
- W2021084899 cites W2108445337 @default.
- W2021084899 cites W2109029867 @default.
- W2021084899 cites W2112748508 @default.
- W2021084899 cites W2115024557 @default.
- W2021084899 cites W2116262526 @default.
- W2021084899 cites W2117757623 @default.
- W2021084899 cites W2119182059 @default.
- W2021084899 cites W2122664093 @default.
- W2021084899 cites W2126180822 @default.
- W2021084899 cites W2126669478 @default.
- W2021084899 cites W2127221509 @default.
- W2021084899 cites W2127977816 @default.
- W2021084899 cites W2129115323 @default.
- W2021084899 cites W2131563799 @default.
- W2021084899 cites W2136651521 @default.
- W2021084899 cites W2139604805 @default.
- W2021084899 cites W2139719760 @default.
- W2021084899 cites W2140166442 @default.
- W2021084899 cites W2141154569 @default.
- W2021084899 cites W2142760199 @default.
- W2021084899 cites W2143616661 @default.
- W2021084899 cites W2146171603 @default.
- W2021084899 cites W2147038307 @default.
- W2021084899 cites W2153040975 @default.
- W2021084899 cites W2159943906 @default.
- W2021084899 cites W2170955899 @default.
- W2021084899 cites W2886978647 @default.
- W2021084899 cites W2937686481 @default.
- W2021084899 cites W3299410 @default.
- W2021084899 cites W4240211429 @default.
- W2021084899 cites W4243069523 @default.
- W2021084899 cites W4302323262 @default.
- W2021084899 doi "https://doi.org/10.1016/j.ajpath.2011.04.025" @default.
- W2021084899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3157286" @default.
- W2021084899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21699881" @default.
- W2021084899 hasPublicationYear "2011" @default.