FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021090260> ?p ?o ?g. }

• W2021090260 endingPage "1708" @default.
• W2021090260 startingPage "1700" @default.
• W2021090260 abstract "Although 1-anilino-naphthalene-8-sulfonate (ANS) has been widely used in protein folding and binding studies, the detailed mechanism of this interaction is not fully understood. In this work the binding of ANS was analyzed at pre-equilibrium and equilibrium conditions using bovine serum albumin (BSA) as model. We employed a combined approach including the analysis of fluorescence, near-UV circular dichroism and isothermal titration calorimetric data. Experiments at equilibrium with these techniques identify three ANS molecules bound at hydrophobic cavities in BSA. Pre-equilibrium fluorescence analysis unambiguously indicated that the binding of ANS at hydrophobic cavities of BSA occurs at two different and independent classes of sites with similar affinities and quantum yields, two features that are undetectable by the equilibrium analysis. The binding of ANS to the first site is thermodynamically favored by similar contributions of the enthalpic (ΔH = − 22 kJ/mol) and entropic terms (− TΔS = − 17 kJ/mol), while the binding to the second site is enthalpically driven (ΔH = − 31 kJ/mol; − TΔS = − 0.6 kJ/mol). Complementary information from molecular docking showed three ANS molecules bound at hydrophobic cavities in BSA subdomains IIA and IIIA with binding affinities in the order of those found experimentally and three additional ANS molecules bound at water exposed sites." @default.
• W2021090260 created "2016-06-24" @default.
• W2021090260 creator A5031895176 @default.
• W2021090260 creator A5032609525 @default.
• W2021090260 creator A5080918059 @default.
• W2021090260 date "2009-11-01" @default.
• W2021090260 modified "2023-10-07" @default.
• W2021090260 title "Kinetics and thermodynamics of the interaction of 1-anilino-naphthalene-8-sulfonate with proteins" @default.
• W2021090260 cites W1504792186 @default.
• W2021090260 cites W1547655165 @default.
• W2021090260 cites W1963908135 @default.
• W2021090260 cites W1969243562 @default.
• W2021090260 cites W1980078657 @default.
• W2021090260 cites W1990160772 @default.
• W2021090260 cites W1994153719 @default.
• W2021090260 cites W1994930430 @default.
• W2021090260 cites W1997364324 @default.
• W2021090260 cites W2001090004 @default.
• W2021090260 cites W2013848575 @default.
• W2021090260 cites W2015642465 @default.
• W2021090260 cites W2016401253 @default.
• W2021090260 cites W2053718841 @default.
• W2021090260 cites W2057291233 @default.
• W2021090260 cites W2058398180 @default.
• W2021090260 cites W2065064126 @default.
• W2021090260 cites W2071419935 @default.
• W2021090260 cites W2090647117 @default.
• W2021090260 cites W2090893400 @default.
• W2021090260 cites W2094707912 @default.
• W2021090260 cites W2099443896 @default.
• W2021090260 cites W2104017463 @default.
• W2021090260 cites W2130292812 @default.
• W2021090260 cites W2130422216 @default.
• W2021090260 cites W2136526507 @default.
• W2021090260 cites W2136898184 @default.
• W2021090260 cites W2145538573 @default.
• W2021090260 cites W2153207080 @default.
• W2021090260 cites W2158534713 @default.
• W2021090260 cites W2234971772 @default.
• W2021090260 cites W2416712998 @default.
• W2021090260 cites W2949472289 @default.
• W2021090260 cites W3004977236 @default.
• W2021090260 doi "https://doi.org/10.1016/j.bbapap.2009.08.007" @default.
• W2021090260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19683079" @default.
• W2021090260 hasPublicationYear "2009" @default.
• W2021090260 type Work @default.
• W2021090260 sameAs 2021090260 @default.
• W2021090260 citedByCount "76" @default.
• W2021090260 countsByYear W20210902602012 @default.
• W2021090260 countsByYear W20210902602013 @default.
• W2021090260 countsByYear W20210902602014 @default.
• W2021090260 countsByYear W20210902602015 @default.
• W2021090260 countsByYear W20210902602016 @default.
• W2021090260 countsByYear W20210902602017 @default.
• W2021090260 countsByYear W20210902602018 @default.
• W2021090260 countsByYear W20210902602019 @default.
• W2021090260 countsByYear W20210902602020 @default.
• W2021090260 countsByYear W20210902602021 @default.
• W2021090260 countsByYear W20210902602022 @default.
• W2021090260 countsByYear W20210902602023 @default.
• W2021090260 crossrefType "journal-article" @default.
• W2021090260 hasAuthorship W2021090260A5031895176 @default.
• W2021090260 hasAuthorship W2021090260A5032609525 @default.
• W2021090260 hasAuthorship W2021090260A5080918059 @default.
• W2021090260 hasConcept C107824862 @default.
• W2021090260 hasConcept C121332964 @default.
• W2021090260 hasConcept C133571119 @default.
• W2021090260 hasConcept C147789679 @default.
• W2021090260 hasConcept C148898269 @default.
• W2021090260 hasConcept C178790620 @default.
• W2021090260 hasConcept C184866935 @default.
• W2021090260 hasConcept C185592680 @default.
• W2021090260 hasConcept C2778894819 @default.
• W2021090260 hasConcept C2780283098 @default.
• W2021090260 hasConcept C32909587 @default.
• W2021090260 hasConcept C43617362 @default.
• W2021090260 hasConcept C537181965 @default.
• W2021090260 hasConcept C55493867 @default.
• W2021090260 hasConcept C62520636 @default.
• W2021090260 hasConcept C71240020 @default.
• W2021090260 hasConcept C8010536 @default.
• W2021090260 hasConcept C86807702 @default.
• W2021090260 hasConcept C90260826 @default.
• W2021090260 hasConcept C91881484 @default.
• W2021090260 hasConceptScore W2021090260C107824862 @default.
• W2021090260 hasConceptScore W2021090260C121332964 @default.
• W2021090260 hasConceptScore W2021090260C133571119 @default.
• W2021090260 hasConceptScore W2021090260C147789679 @default.
• W2021090260 hasConceptScore W2021090260C148898269 @default.
• W2021090260 hasConceptScore W2021090260C178790620 @default.
• W2021090260 hasConceptScore W2021090260C184866935 @default.
• W2021090260 hasConceptScore W2021090260C185592680 @default.
• W2021090260 hasConceptScore W2021090260C2778894819 @default.
• W2021090260 hasConceptScore W2021090260C2780283098 @default.
• W2021090260 hasConceptScore W2021090260C32909587 @default.
• W2021090260 hasConceptScore W2021090260C43617362 @default.
• W2021090260 hasConceptScore W2021090260C537181965 @default.
• W2021090260 hasConceptScore W2021090260C55493867 @default.

• next