FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021091062> ?p ?o ?g. }

• W2021091062 endingPage "8034" @default.
• W2021091062 startingPage "8022" @default.
• W2021091062 abstract "The maintained expression of transcription factors throughout the development of mesodiencephalic dopaminergic (mDA) neurons suggests multiple roles at various stages in development. Two members of the forkhead/winged helix transcription factor family, Foxa1 and Foxa2, have been recently shown to have an important influence in the early development of mDA neurons. Here we present data demonstrating that these genes are also involved in the later maintenance of the mDA system. We conditionally removed both genes in postmitotic mDA neurons using the dopamine transporter-cre mouse. Deletion of both Foxa1 and Foxa2 resulted in a significant reduction in the number of tyrosine hydroxylase (TH)-positive mDA neurons. The decrease was predominantly observed in the substantia nigra region of the mDA system, which led to a loss of TH+ fibers innervating the striatum. Further analysis demonstrated that the reduction in the number of TH+ cells in the mutant mice was not due to apoptosis or cell-fate change. Using reporter mouse lines, we found that the mDA neurons were still present in the ventral midbrain, but that they had lost much of their dopaminergic phenotype. The majority of these neurons remained in the ventral mesencephalon until at least 18 months of age. Chromatin immunoprecipitation suggested that the loss of the mDA phenotype is due to a reduction in the binding of the nuclear orphan receptor, Nurr-1 to the promoter region of TH. These results extend previous findings and demonstrate a later role for Foxa genes in regulating the maintenance of dopaminergic phenotype in mDA neurons." @default.
• W2021091062 created "2016-06-24" @default.
• W2021091062 creator A5012746992 @default.
• W2021091062 creator A5040427737 @default.
• W2021091062 creator A5046924211 @default.
• W2021091062 creator A5052145237 @default.
• W2021091062 creator A5074464568 @default.
• W2021091062 creator A5081061069 @default.
• W2021091062 date "2013-05-01" @default.
• W2021091062 modified "2023-10-16" @default.
• W2021091062 title "Foxa1 and Foxa2 Are Required for the Maintenance of Dopaminergic Properties in Ventral Midbrain Neurons at Late Embryonic Stages" @default.
• W2021091062 cites W1618939505 @default.
• W2021091062 cites W1658437261 @default.
• W2021091062 cites W1930652382 @default.
• W2021091062 cites W1968034152 @default.
• W2021091062 cites W1973549214 @default.
• W2021091062 cites W1973897139 @default.
• W2021091062 cites W1976194722 @default.
• W2021091062 cites W1979377389 @default.
• W2021091062 cites W1982630660 @default.
• W2021091062 cites W1987028639 @default.
• W2021091062 cites W1993634104 @default.
• W2021091062 cites W2010163698 @default.
• W2021091062 cites W2014077626 @default.
• W2021091062 cites W2024931422 @default.
• W2021091062 cites W2025518768 @default.
• W2021091062 cites W2029821696 @default.
• W2021091062 cites W2034564714 @default.
• W2021091062 cites W2043269926 @default.
• W2021091062 cites W2045261317 @default.
• W2021091062 cites W2048022386 @default.
• W2021091062 cites W2061505696 @default.
• W2021091062 cites W2072837173 @default.
• W2021091062 cites W2073751853 @default.
• W2021091062 cites W2074145762 @default.
• W2021091062 cites W2082347868 @default.
• W2021091062 cites W2083092470 @default.
• W2021091062 cites W2086046051 @default.
• W2021091062 cites W2091040966 @default.
• W2021091062 cites W2093600932 @default.
• W2021091062 cites W2095818814 @default.
• W2021091062 cites W2098946501 @default.
• W2021091062 cites W2108851964 @default.
• W2021091062 cites W2109191553 @default.
• W2021091062 cites W2109627278 @default.
• W2021091062 cites W2117297895 @default.
• W2021091062 cites W2126940311 @default.
• W2021091062 cites W2127510589 @default.
• W2021091062 cites W2131848867 @default.
• W2021091062 cites W2136898873 @default.
• W2021091062 cites W2137195455 @default.
• W2021091062 cites W2139148195 @default.
• W2021091062 cites W2154069538 @default.
• W2021091062 cites W2156933633 @default.
• W2021091062 cites W2158662449 @default.
• W2021091062 cites W2171298950 @default.
• W2021091062 cites W2183066763 @default.
• W2021091062 cites W2187208469 @default.
• W2021091062 cites W2398849569 @default.
• W2021091062 cites W61927212 @default.
• W2021091062 doi "https://doi.org/10.1523/jneurosci.4774-12.2013" @default.
• W2021091062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6618950" @default.
• W2021091062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23637192" @default.
• W2021091062 hasPublicationYear "2013" @default.
• W2021091062 type Work @default.
• W2021091062 sameAs 2021091062 @default.
• W2021091062 citedByCount "71" @default.
• W2021091062 countsByYear W20210910622013 @default.
• W2021091062 countsByYear W20210910622014 @default.
• W2021091062 countsByYear W20210910622015 @default.
• W2021091062 countsByYear W20210910622016 @default.
• W2021091062 countsByYear W20210910622017 @default.
• W2021091062 countsByYear W20210910622018 @default.
• W2021091062 countsByYear W20210910622019 @default.
• W2021091062 countsByYear W20210910622020 @default.
• W2021091062 countsByYear W20210910622021 @default.
• W2021091062 countsByYear W20210910622022 @default.
• W2021091062 countsByYear W20210910622023 @default.
• W2021091062 crossrefType "journal-article" @default.
• W2021091062 hasAuthorship W2021091062A5012746992 @default.
• W2021091062 hasAuthorship W2021091062A5040427737 @default.
• W2021091062 hasAuthorship W2021091062A5046924211 @default.
• W2021091062 hasAuthorship W2021091062A5052145237 @default.
• W2021091062 hasAuthorship W2021091062A5074464568 @default.
• W2021091062 hasAuthorship W2021091062A5081061069 @default.
• W2021091062 hasBestOaLocation W20210910621 @default.
• W2021091062 hasConcept C101762097 @default.
• W2021091062 hasConcept C104317684 @default.
• W2021091062 hasConcept C127716648 @default.
• W2021091062 hasConcept C134320426 @default.
• W2021091062 hasConcept C137183658 @default.
• W2021091062 hasConcept C148397407 @default.
• W2021091062 hasConcept C150194340 @default.
• W2021091062 hasConcept C154456304 @default.
• W2021091062 hasConcept C159167319 @default.
• W2021091062 hasConcept C169760540 @default.
• W2021091062 hasConcept C2780062018 @default.
• W2021091062 hasConcept C2780938664 @default.

• next