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• W2021093068 abstract "BackgroundTo define the relationship between regional coronary vasodilator capacity and myocardial circumferential strain at rest in normal weight, overweight, and obese individuals with normal global left-ventricular function.Methods and ResultsMyocardial blood flow at rest and during pharmacologic vasodilation was measured with 13N-ammonia PET/CT in mL/g/minute in normal weight control (CON, n = 12), overweight (OW, n = 10), and obese individuals (OB, n = 10). In addition, resting myocardial function was evaluated as circumferential strain (Єc, %) by MRI. Global myocardial flow reserve (MFR) did not differ significantly between CON and OW (2.98 ± 0.96 vs 2.70 ± 0.66, P = .290), whereas it declined significantly in OB (1.98 ± 1.04, P = .030). Further, global Єc (%) was comparable between CON, OW, and OB (−0.24 ± 0.03, −0.23 ± 0.02, and −0.23 ± 0.04) but it was lowest in OB when normalized to the rate-pressure product (NЄc: −0.31 ± 0.06, −0.32 ± 0.05, and −0.26 ± 0.08). When MFR of the three major coronary territories was correlated with corresponding Єc, a positive association was observed in CON (r = 0.36, P = .030), in OW (r = 0.54, P = .002), and also in OB when relating NЄc to coronary vascular resistance during pharmacologic vasodilation (r = −0.46, P = .010).ConclusionsHigher coronary vasodilator capacity is related to corresponding regional circumferential strain at rest in non-obese individuals, while this is also observed for reduced MFR in obesity." @default.
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• W2021093068 date "2012-04-28" @default.
• W2021093068 modified "2023-10-18" @default.
• W2021093068 title "Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight" @default.
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• W2021093068 doi "https://doi.org/10.1007/s12350-012-9570-5" @default.
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