FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021096341> ?p ?o ?g. }

• W2021096341 endingPage "292" @default.
• W2021096341 startingPage "289" @default.
• W2021096341 abstract "BRAF and RAS are often mutated in cutaneous melanoma and both mutations stimulate the MAPK pathway. However the biological consequences of BRAF and NRAS mutations are different because when RAS is mutated in melanoma, cells use CRAF rather than BRAF to activate MEK / ERK. The mechanism of this BRAF to CRAF isoform switching in response to oncogenic RAS has recently been described. Activation of the MAPK pathway, which results from a mutation of NRAS, induces phosphorylation of BRAF on serine 151 by ERK which prevents its binding to NRAS. To circumvent this negative feedback inhibition of BRAF, melanoma cells containing a mutation of RAS use CRAF to activate MEK / ERK. However, because the cAMP pathway in melanocytes constitutively inhibits CRAF, RAF isoform switching in melanoma is accompanied by an inhibition of the cAMP pathway. This inhibition is due to an increase in phosphodiesterase activity, which degrades cAMP thereby preventing inhibition of CRAF by PKA. These data highlight the importance of CRAF downstream of oncogenic Ras in tumor development." @default.
• W2021096341 created "2016-06-24" @default.
• W2021096341 creator A5069199796 @default.
• W2021096341 date "2011-09-01" @default.
• W2021096341 modified "2023-09-30" @default.
• W2021096341 title "Mechanism of RAF isoform switching induced by oncogenic RAS in melanoma" @default.
• W2021096341 cites W1570494660 @default.
• W2021096341 cites W1595732636 @default.
• W2021096341 cites W1967612766 @default.
• W2021096341 cites W1968664688 @default.
• W2021096341 cites W1974004551 @default.
• W2021096341 cites W2003349514 @default.
• W2021096341 cites W2004295816 @default.
• W2021096341 cites W2006282831 @default.
• W2021096341 cites W2017187984 @default.
• W2021096341 cites W2018058179 @default.
• W2021096341 cites W2024085992 @default.
• W2021096341 cites W2029557430 @default.
• W2021096341 cites W2042015701 @default.
• W2021096341 cites W2048672579 @default.
• W2021096341 cites W2049171090 @default.
• W2021096341 cites W2051165598 @default.
• W2021096341 cites W2054259191 @default.
• W2021096341 cites W2054292493 @default.
• W2021096341 cites W2067738389 @default.
• W2021096341 cites W2070871778 @default.
• W2021096341 cites W2074089133 @default.
• W2021096341 cites W2079216025 @default.
• W2021096341 cites W2080686146 @default.
• W2021096341 cites W2081527131 @default.
• W2021096341 cites W2100614336 @default.
• W2021096341 cites W2102646127 @default.
• W2021096341 cites W2105726821 @default.
• W2021096341 cites W2106543129 @default.
• W2021096341 cites W2107077893 @default.
• W2021096341 cites W2133177414 @default.
• W2021096341 cites W2144708319 @default.
• W2021096341 cites W2149662085 @default.
• W2021096341 cites W2160378889 @default.
• W2021096341 cites W2161018320 @default.
• W2021096341 doi "https://doi.org/10.4161/sgtp.2.5.17814" @default.
• W2021096341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3265821" @default.
• W2021096341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22292133" @default.
• W2021096341 hasPublicationYear "2011" @default.
• W2021096341 type Work @default.
• W2021096341 sameAs 2021096341 @default.
• W2021096341 citedByCount "30" @default.
• W2021096341 countsByYear W20210963412012 @default.
• W2021096341 countsByYear W20210963412013 @default.
• W2021096341 countsByYear W20210963412014 @default.
• W2021096341 countsByYear W20210963412015 @default.
• W2021096341 countsByYear W20210963412016 @default.
• W2021096341 countsByYear W20210963412017 @default.
• W2021096341 countsByYear W20210963412019 @default.
• W2021096341 countsByYear W20210963412020 @default.
• W2021096341 countsByYear W20210963412022 @default.
• W2021096341 countsByYear W20210963412023 @default.
• W2021096341 crossrefType "journal-article" @default.
• W2021096341 hasAuthorship W2021096341A5069199796 @default.
• W2021096341 hasBestOaLocation W20210963411 @default.
• W2021096341 hasConcept C104317684 @default.
• W2021096341 hasConcept C1167327 @default.
• W2021096341 hasConcept C11960822 @default.
• W2021096341 hasConcept C21790070 @default.
• W2021096341 hasConcept C2777658100 @default.
• W2021096341 hasConcept C2781187634 @default.
• W2021096341 hasConcept C501734568 @default.
• W2021096341 hasConcept C502942594 @default.
• W2021096341 hasConcept C53345823 @default.
• W2021096341 hasConcept C54355233 @default.
• W2021096341 hasConcept C57074206 @default.
• W2021096341 hasConcept C86803240 @default.
• W2021096341 hasConcept C95444343 @default.
• W2021096341 hasConceptScore W2021096341C104317684 @default.
• W2021096341 hasConceptScore W2021096341C1167327 @default.
• W2021096341 hasConceptScore W2021096341C11960822 @default.
• W2021096341 hasConceptScore W2021096341C21790070 @default.
• W2021096341 hasConceptScore W2021096341C2777658100 @default.
• W2021096341 hasConceptScore W2021096341C2781187634 @default.
• W2021096341 hasConceptScore W2021096341C501734568 @default.
• W2021096341 hasConceptScore W2021096341C502942594 @default.
• W2021096341 hasConceptScore W2021096341C53345823 @default.
• W2021096341 hasConceptScore W2021096341C54355233 @default.
• W2021096341 hasConceptScore W2021096341C57074206 @default.
• W2021096341 hasConceptScore W2021096341C86803240 @default.
• W2021096341 hasConceptScore W2021096341C95444343 @default.
• W2021096341 hasIssue "5" @default.
• W2021096341 hasLocation W20210963411 @default.
• W2021096341 hasLocation W20210963412 @default.
• W2021096341 hasLocation W20210963413 @default.
• W2021096341 hasLocation W20210963414 @default.
• W2021096341 hasOpenAccess W2021096341 @default.
• W2021096341 hasPrimaryLocation W20210963411 @default.
• W2021096341 hasRelatedWork W135432848 @default.
• W2021096341 hasRelatedWork W1968041503 @default.
• W2021096341 hasRelatedWork W2141202463 @default.
• W2021096341 hasRelatedWork W2164992866 @default.
• W2021096341 hasRelatedWork W2325896084 @default.

• next