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- W2021096632 abstract "To evaluate potential improvement in tissue specific targeting and cellular uptake of therapeutic ribozymes, we have developed three new phosphoramidite reagents. These reagents can be used in automated solid-phase synthesis to produce oligonucleotide conjugates containing N-acetyl-D-galactosamine (targeting hepatocytes) and folic acid (targeting tumor). N-Acetyl-D-galactosamine was attached through a linker to both 2'-amino-2'-deoxyuridine and D-threoninol scaffolds, and these conjugates were converted to phosphoramidite building blocks. Incorporation of a D-threoninol-based monomer into ribozymes provided multiply labeled ribozyme conjugates. Attachment of the fully protected pteroic acid to the D-threoninol-6-aminocaproyl-L-glutamic acid construct afforded the folic acid conjugate, which was converted into the phosphoramidite and incorporated onto the 5'-end of the ribozyme." @default.
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- W2021096632 date "2002-07-10" @default.
- W2021096632 modified "2023-09-26" @default.
- W2021096632 title "Synthesis of <i>N</i>-Acetyl-<scp>d</scp>-galactosamine and Folic Acid Conjugated Ribozymes" @default.
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- W2021096632 doi "https://doi.org/10.1021/bc025525q" @default.
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