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- W2021097795 abstract "Ovarian hyperstimulation syndrome (OHSS) is a complication of assisted reproductive technologies (ARTs). The cardiovascular dysfunction in children born with ARTs has been widely concerned. However, whether OHSS is associated with worse cardiovascular functions and the mechanisms underlying the association remain unknown. A retrospective cohort and a proteomics analysis. We assessed cardiovascular functions by Doppler echography in 42 children born to OHSS women, 34 children conceived with non-OHSS In Vitro Fertilization (IVF) and 48 spontaneous conceived (SC) children (mean age about 4.5 years). We performed an iTRAQ labeled proteomics analysis with another set of umbilical cords from OHSS and SC pregnancies. One-way ANOVA followed by LSD post hoc test and two-tailed Fisher’s exact tests were used, as appropriate. OHSS children showed a significantly decreased mitral E/A ratio compared with SC children while left ventricular ejection fraction, shortening fraction, and isovolumic relaxation time were comparable. OHSS children showed reduced systolic and diastolic diameters of common carotid arteries and impaired flow-mediated dilation compared with non-OHSS IVF and SC children. Intima-media thickness and arterial stiffness indices were similar in three groups. In proteomics study, 1640 proteins were identified from OHSS and SC umbilical arteries, and, 39 differentially expressed proteins were selected for further analysis. Estradiol was identified as activated upstream regulators. Children born to women with OHSS displayed cardiovascular dysfunctions. The underlying mechanisms may involve the effect of supraphysiological estradiol levels." @default.
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- W2021097795 date "2014-09-01" @default.
- W2021097795 modified "2023-09-29" @default.
- W2021097795 title "Cardiovascular dysfunction in children born to women with ovarian hyperstimulation syndrome: a retrospective cohort study and proteomics analysis" @default.
- W2021097795 doi "https://doi.org/10.1016/j.fertnstert.2014.07.087" @default.
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