Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021103732> ?p ?o ?g. }
- W2021103732 endingPage "548" @default.
- W2021103732 startingPage "538" @default.
- W2021103732 abstract "Normal cardiac function requires a tight interaction between metabolism, contractile function and gene expression. The main perturbation challenging this equilibrium in vivo is ischemia, which alters energy flux through the control of key enzymes. The review highlights metabolic imprints and energetic aspects of programmed cell survival, programmed cell death, and of necrosis. When sustained and severe, ischemia leads to a total collapse of energy transfer, to the accumulation of metabolic endproducts, and to the development of myocardial necrosis. When moderate, ischemia results in a coordinated cellular response including enhanced anaerobic glucose metabolism, a modification of cardiac gene expression, and the development of specific mechanisms for programmed cell survival (preconditioning, stunning, hibernation). Repetitive stress results in a decrease of contractile function, a downregulation of gene expression and an impairment of energy transfer, which eventually cause the heart to fail. When the failing heart becomes energy-depleted, the programs of cell survival are no longer operational and programmed cell death ensues. To define the point of departure from programmed cell survival to cell death remains a major challenge." @default.
- W2021103732 created "2016-06-24" @default.
- W2021103732 creator A5010780253 @default.
- W2021103732 creator A5018935225 @default.
- W2021103732 date "2000-02-01" @default.
- W2021103732 modified "2023-09-24" @default.
- W2021103732 title "Metabolic aspects of programmed cell survival and cell death in the heart" @default.
- W2021103732 cites W146700098 @default.
- W2021103732 cites W1481638738 @default.
- W2021103732 cites W1497671643 @default.
- W2021103732 cites W1505838412 @default.
- W2021103732 cites W1515833925 @default.
- W2021103732 cites W1531062343 @default.
- W2021103732 cites W1572887479 @default.
- W2021103732 cites W1596644386 @default.
- W2021103732 cites W1601923831 @default.
- W2021103732 cites W1608143264 @default.
- W2021103732 cites W162680354 @default.
- W2021103732 cites W1706711569 @default.
- W2021103732 cites W1709366947 @default.
- W2021103732 cites W1750720387 @default.
- W2021103732 cites W1764308599 @default.
- W2021103732 cites W1802422726 @default.
- W2021103732 cites W1897809699 @default.
- W2021103732 cites W1906722545 @default.
- W2021103732 cites W1934620989 @default.
- W2021103732 cites W1964659656 @default.
- W2021103732 cites W1966753868 @default.
- W2021103732 cites W1967128858 @default.
- W2021103732 cites W1967506260 @default.
- W2021103732 cites W1968126642 @default.
- W2021103732 cites W1975563075 @default.
- W2021103732 cites W1976680355 @default.
- W2021103732 cites W1977596244 @default.
- W2021103732 cites W1978220492 @default.
- W2021103732 cites W1979460016 @default.
- W2021103732 cites W1980165156 @default.
- W2021103732 cites W1981576632 @default.
- W2021103732 cites W1983816549 @default.
- W2021103732 cites W1984510165 @default.
- W2021103732 cites W1987664769 @default.
- W2021103732 cites W1987790381 @default.
- W2021103732 cites W1988031820 @default.
- W2021103732 cites W1989021071 @default.
- W2021103732 cites W1990665368 @default.
- W2021103732 cites W1993807577 @default.
- W2021103732 cites W1994428083 @default.
- W2021103732 cites W1995893669 @default.
- W2021103732 cites W1997832379 @default.
- W2021103732 cites W1999242870 @default.
- W2021103732 cites W2001333805 @default.
- W2021103732 cites W2002499022 @default.
- W2021103732 cites W2002526689 @default.
- W2021103732 cites W2006554180 @default.
- W2021103732 cites W2007533297 @default.
- W2021103732 cites W2008434058 @default.
- W2021103732 cites W2010791119 @default.
- W2021103732 cites W2012444458 @default.
- W2021103732 cites W2012561199 @default.
- W2021103732 cites W2013979638 @default.
- W2021103732 cites W2014942570 @default.
- W2021103732 cites W2017721730 @default.
- W2021103732 cites W2020971669 @default.
- W2021103732 cites W2021927708 @default.
- W2021103732 cites W2022480548 @default.
- W2021103732 cites W2024306318 @default.
- W2021103732 cites W2024398910 @default.
- W2021103732 cites W2029218110 @default.
- W2021103732 cites W2029651486 @default.
- W2021103732 cites W2030956146 @default.
- W2021103732 cites W2031675072 @default.
- W2021103732 cites W2033469209 @default.
- W2021103732 cites W2033767220 @default.
- W2021103732 cites W2033858209 @default.
- W2021103732 cites W2036227941 @default.
- W2021103732 cites W2036878457 @default.
- W2021103732 cites W2042928324 @default.
- W2021103732 cites W2043474235 @default.
- W2021103732 cites W2046550786 @default.
- W2021103732 cites W2048404789 @default.
- W2021103732 cites W2049116931 @default.
- W2021103732 cites W2050552736 @default.
- W2021103732 cites W2054220851 @default.
- W2021103732 cites W2055330931 @default.
- W2021103732 cites W2056982291 @default.
- W2021103732 cites W2059215353 @default.
- W2021103732 cites W2059357264 @default.
- W2021103732 cites W2060300790 @default.
- W2021103732 cites W2061092938 @default.
- W2021103732 cites W2061144992 @default.
- W2021103732 cites W2061413661 @default.
- W2021103732 cites W2062919057 @default.
- W2021103732 cites W2063594418 @default.
- W2021103732 cites W2064018881 @default.
- W2021103732 cites W2065201989 @default.
- W2021103732 cites W2065907781 @default.
- W2021103732 cites W2067539483 @default.
- W2021103732 cites W2067601335 @default.