FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021104522> ?p ?o ?g. }

• W2021104522 endingPage "1444" @default.
• W2021104522 startingPage "1440" @default.
• W2021104522 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 May 2000BLADDER STRETCH ALTERS URINARY HEPARIN-BINDING EPIDERMAL GROWTH FACTOR AND ANTIPROLIFERATIVE FACTOR IN PATIENTS WITH INTERSTITIAL CYSTITIS TOBY C. CHAI, CHEN-OU ZHANG, JOANNA L. SHOENFELT, HARRY W. JOHNSON, JOHN W. WARREN, and SUSAN KEAY TOBY C. CHAITOBY C. CHAI More articles by this author , CHEN-OU ZHANGCHEN-OU ZHANG More articles by this author , JOANNA L. SHOENFELTJOANNA L. SHOENFELT More articles by this author , HARRY W. JOHNSONHARRY W. JOHNSON More articles by this author , JOHN W. WARRENJOHN W. WARREN More articles by this author , and SUSAN KEAYSUSAN KEAY More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67638-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The etiology of interstitial cystitis is unknown. Urine from patients with interstitial cystitis has been shown to inhibit urothelial proliferation through a putative antiproliferative factor and to contain decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) compared to controls. Stretch of detrusor smooth muscle cells is known to stimulate HB-EGF production. Because bladder hydrodistention sometimes alleviates the symptoms of interstitial cystitis, we determined whether the stretch stimulus of hydrodistention alters antiproliferative factor activity and/or HB-EGF in interstitial cystitis urine specimens. Materials and Methods: Urine was collected immediately before, and 2 to 4 hours and 2 weeks after hydrodistention from 15 patients with symptoms and cystoscopic findings compatible with interstitial cystitis and 13 controls. Hydrodistention was performed with the subject under general or regional anesthesia and bladders were distended to 80 cm. water 3 times. Urinary HB-EGF was measured by enzyme-linked immunosorbent assay and urinary antiproliferative factor activity was determined by measuring 3H-thymidine uptake by normal human bladder urothelial cells. Results: Hydrodistention significantly increased urinary HB-EGF in patients with interstitial cystitis toward normal control values (before distention p = 0.003, 2 weeks after distention p = 0.67). Urine antiproliferative factor activity decreased significantly after hydrodistention in patients with interstitial cystitis. However, antiproliferative factor activity in interstitial cystitis and control specimens was still statistically different 2 weeks after distention (before distention p = 0.0000004, 2 weeks after distention p = 0.04). Conclusions: Bladder stretch increased HB-EGF and conversely reduced antiproliferative factor activity in urine from patients with interstitial cystitis but not controls up to 2 weeks after distention. These results provide additional evidence for the possible role of antiproliferative factor and decreased HB-EGF in the pathophysiology of interstitial cystitis. To our knowledge this is also the first human study to show that in vivo bladder stretch can alter urinary factors that regulate cell growth. References 1 : Interstitial cystitis: a critique of current concepts with a new proposal for pathologic diagnosis and pathogenesis. Urology1997; 49: 14. Google Scholar 2 : Decreased 3H-thymidine incorporation by human bladder epithelial cells following exposure to urine from interstitial cystitis patients. J Urol1996; 156: 2073. Link, Google Scholar 3 : A diagnostic in vitro urine assay for interstitial cystitis. Urology1998; 52: 974. Google Scholar 4 : Concentrations of specific epithelial growth factors in the urine of interstitial cystitis patients and controls. J Urol1997; 158: 1983. Link, Google Scholar 5 : Interstitial cystitis: its treatment by overdistention of the bladder. Med Clin North Am1930; 13: 1495. Google Scholar 6 : Protein kinase C in cyclic stretch-induced nerve growth factor production by urinary tract smooth muscle cells. Am J Physiol1995; 269: C1018. Google Scholar 7 : Mechanical stretch increases secretion of parathyroid hormone-related protein by cultured bladder smooth muscle cells. J Urol1998; 160: 908. Link, Google Scholar 8 : Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells. Am J Physiol1998; 275: C1247. Google Scholar 9 : Anti-proliferative activity is present in bladder but not renal pelvic urine from interstitial cystitis patients. J Urol1999; 162: 1487. Link, Google Scholar 10 : Cystoscopic findings consistent with interstitial cystitis in normal women undergoing tubal ligation. J Urol1998; 160: 1663. Link, Google Scholar 11 : Discussion. Tr Am Assoc Gen Urin Surg1922; 15: 434. Google Scholar 12 : Successful therapy of interstitial cystitis with pentosanpolysulfate. J Urol1987; 138: 513. Link, Google Scholar 13 : Pentosan polysulfate sodium for therapy of interstitial cystitis. A double-blind placebo-controlled clinical study. Urology1990; 35: 552. Google Scholar 14 : Bladder surface glycosaminoglycans: an epithelial permeability barrier. J Urol1990; 143: 139. Link, Google Scholar 15 : Bladder surface glycosaminoglycans is a human epithelial permeability barrier. Surg Gynecol Obstet1990; 171: 493. Google Scholar 16 : Cell-specific activation of the heparin-binding EGF-like growth factor gene by mechanical stretch in human bladder smooth muscle and urothelial cells. J Urol1999; 161: 42. abstract 151. Google Scholar From the Division of Urology, Department of Surgery, Division of Infectious Diseases, Department of Internal Medicine, and Department of Obstetrics and Gynecology, University of Maryland School of Medicine and Veterans Administration Maryland Health Care System, Baltimore, Maryland© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byZabihi N, Allee T, Maher M, Mourtzinos A, Raz S, Payne C and Rodríguez L (2018) Bladder Necrosis Following Hydrodistention in Patients With Interstitial CystitisJournal of Urology, VOL. 177, NO. 1, (149-152), Online publication date: 1-Jan-2007.Erickson D, Kunselman A, Bentley C, Peters K, Rovner E, Demers L, Wheeler M and Keay S (2018) Changes in Urine Markers and Symptoms After Bladder Distention for Interstitial CystitisJournal of Urology, VOL. 177, NO. 2, (556-560), Online publication date: 1-Feb-2007.Kanai A, de Groat W, Birder L, Chai T, Hultgren S, Fowler C and Fry C (2018) Symposium Report on Urothelial Dysfunction: Pathophysiology and Novel TherapiesJournal of Urology, VOL. 175, NO. 5, (1624-1629), Online publication date: 1-May-2006.TAMAKI M, SAITO R, OGAWA O, YOSHIMURA N and UEDA T (2018) POSSIBLE MECHANISMS INDUCING GLOMERULATIONS IN INTERSTITIAL CYSTITIS: RELATIONSHIP BETWEEN ENDOSCOPIC FINDINGS AND EXPRESSION OF ANGIOGENIC GROWTH FACTORSJournal of Urology, VOL. 172, NO. 3, (945-948), Online publication date: 1-Sep-2004.SUN Y, KEAY S, De DEYNE P and CHAI T (2018) AUGMENTED STRETCH ACTIVATED ADENOSINE TRIPHOSPHATE RELEASE FROM BLADDER UROEPITHELIAL CELLS IN PATIENTS WITH INTERSTITIAL CYSTITISJournal of Urology, VOL. 166, NO. 5, (1951-1956), Online publication date: 1-Nov-2001. Volume 163Issue 5May 2000Page: 1440-1444 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.Keywordscystitis, interstitialheparingrowth substancesbladderepidermal growth factorMetricsAuthor Information TOBY C. CHAI More articles by this author CHEN-OU ZHANG More articles by this author JOANNA L. SHOENFELT More articles by this author HARRY W. JOHNSON More articles by this author JOHN W. WARREN More articles by this author SUSAN KEAY More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
• W2021104522 created "2016-06-24" @default.
• W2021104522 creator A5011086115 @default.
• W2021104522 creator A5014349989 @default.
• W2021104522 creator A5017607205 @default.
• W2021104522 creator A5075011611 @default.
• W2021104522 creator A5077324545 @default.
• W2021104522 creator A5085344926 @default.
• W2021104522 date "2000-05-01" @default.
• W2021104522 modified "2023-09-27" @default.
• W2021104522 title "BLADDER STRETCH ALTERS URINARY HEPARIN-BINDING EPIDERMAL GROWTH FACTOR AND ANTIPROLIFERATIVE FACTOR IN PATIENTS WITH INTERSTITIAL CYSTITIS" @default.
• W2021104522 cites W118551320 @default.
• W2021104522 cites W119791751 @default.
• W2021104522 cites W1554088208 @default.
• W2021104522 cites W1762264738 @default.
• W2021104522 cites W1979342118 @default.
• W2021104522 cites W2003450769 @default.
• W2021104522 cites W2032630018 @default.
• W2021104522 cites W2081899465 @default.
• W2021104522 cites W2087402355 @default.
• W2021104522 cites W2087579384 @default.
• W2021104522 cites W2105392824 @default.
• W2021104522 cites W2124140715 @default.
• W2021104522 cites W2171183523 @default.
• W2021104522 doi "https://doi.org/10.1016/s0022-5347(05)67638-0" @default.
• W2021104522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10751853" @default.
• W2021104522 hasPublicationYear "2000" @default.
• W2021104522 type Work @default.
• W2021104522 sameAs 2021104522 @default.
• W2021104522 citedByCount "76" @default.
• W2021104522 countsByYear W20211045222012 @default.
• W2021104522 countsByYear W20211045222013 @default.
• W2021104522 countsByYear W20211045222014 @default.
• W2021104522 countsByYear W20211045222015 @default.
• W2021104522 countsByYear W20211045222016 @default.
• W2021104522 countsByYear W20211045222017 @default.
• W2021104522 countsByYear W20211045222018 @default.
• W2021104522 countsByYear W20211045222019 @default.
• W2021104522 countsByYear W20211045222021 @default.
• W2021104522 countsByYear W20211045222022 @default.
• W2021104522 crossrefType "journal-article" @default.
• W2021104522 hasAuthorship W2021104522A5011086115 @default.
• W2021104522 hasAuthorship W2021104522A5014349989 @default.
• W2021104522 hasAuthorship W2021104522A5017607205 @default.
• W2021104522 hasAuthorship W2021104522A5075011611 @default.
• W2021104522 hasAuthorship W2021104522A5077324545 @default.
• W2021104522 hasAuthorship W2021104522A5085344926 @default.
• W2021104522 hasConcept C126322002 @default.
• W2021104522 hasConcept C126894567 @default.
• W2021104522 hasConcept C159048773 @default.
• W2021104522 hasConcept C170493617 @default.
• W2021104522 hasConcept C2776362946 @default.
• W2021104522 hasConcept C2777557582 @default.
• W2021104522 hasConcept C2778508898 @default.
• W2021104522 hasConcept C2779762690 @default.
• W2021104522 hasConcept C71924100 @default.
• W2021104522 hasConcept C77411442 @default.
• W2021104522 hasConceptScore W2021104522C126322002 @default.
• W2021104522 hasConceptScore W2021104522C126894567 @default.
• W2021104522 hasConceptScore W2021104522C159048773 @default.
• W2021104522 hasConceptScore W2021104522C170493617 @default.
• W2021104522 hasConceptScore W2021104522C2776362946 @default.
• W2021104522 hasConceptScore W2021104522C2777557582 @default.
• W2021104522 hasConceptScore W2021104522C2778508898 @default.
• W2021104522 hasConceptScore W2021104522C2779762690 @default.
• W2021104522 hasConceptScore W2021104522C71924100 @default.
• W2021104522 hasConceptScore W2021104522C77411442 @default.
• W2021104522 hasIssue "5" @default.
• W2021104522 hasLocation W20211045221 @default.
• W2021104522 hasLocation W20211045222 @default.
• W2021104522 hasOpenAccess W2021104522 @default.
• W2021104522 hasPrimaryLocation W20211045221 @default.
• W2021104522 hasRelatedWork W1547020019 @default.
• W2021104522 hasRelatedWork W183249409 @default.
• W2021104522 hasRelatedWork W196898746 @default.
• W2021104522 hasRelatedWork W2002588245 @default.
• W2021104522 hasRelatedWork W2039221211 @default.
• W2021104522 hasRelatedWork W2071073667 @default.
• W2021104522 hasRelatedWork W2073189641 @default.
• W2021104522 hasRelatedWork W2288738892 @default.
• W2021104522 hasRelatedWork W4235712915 @default.
• W2021104522 hasRelatedWork W2515702027 @default.
• W2021104522 hasVolume "163" @default.
• W2021104522 isParatext "false" @default.
• W2021104522 isRetracted "false" @default.
• W2021104522 magId "2021104522" @default.
• W2021104522 workType "article" @default.