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• W2021105570 abstract "The intracellular part of the Rel signal transduction pathway in Drosophila is encoded by Toll , tube , pelle , dorsal , and cactus , and it functions to form the dorsal–ventral axis in the Drosophila embryo. Upon activation of the transmembrane receptor Toll, Dorsal dissociates from its cytoplasmic inhibitor Cactus and enters the nucleus. Tube and Pelle are required to relay the signal from Toll to the Dorsal–Cactus complex. In a yeast two-hybrid assay, we found that both Tube and Pelle interact with Dorsal. We confirmed these interactions in an in vitro binding assay. Tube interacts with Dorsal via its C-terminal domain, whereas full-length Pelle is required for Dorsal binding. Tube and Pelle bind Dorsal in the N-terminal domain 1 of the Dorsal Rel homology region rather than at the Cactus binding site. Domain 1 has been found to be necessary for Dorsal nuclear targeting. Genetic experiments indicate that Tube–Dorsal interaction is necessary for normal signal transduction. We propose a model in which Tube, Pelle, Cactus, and Dorsal form a multimeric complex that represents an essential aspect of signal transduction." @default.
• W2021105570 created "2016-06-24" @default.
• W2021105570 creator A5014389365 @default.
• W2021105570 creator A5083203133 @default.
• W2021105570 date "1997-12-23" @default.
• W2021105570 modified "2023-09-27" @default.
• W2021105570 title "A multimeric complex and the nuclear targeting of the <i>Drosophila</i> Rel protein Dorsal" @default.
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• W2021105570 doi "https://doi.org/10.1073/pnas.94.26.14524" @default.
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