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- W2021105966 endingPage "628" @default.
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- W2021105966 abstract "The mature B cell compartment of MHC class II-deficient B6 I-Aalpha(-/-) and the btk-defective CBA/N mouse strain is 4- to 5-fold smaller than in wild-type B6 mice. The defect in B6 I-Aalpha(-/-) mice is intrinsic to B cells and due to a 4- to 5-fold reduced lifespan, which however can be normalized by an I-Ealpha(d) transgene, but only when expressed early during B cell development. The reduced number of mature B cells in the btk-defective CBA/N mouse is due to a 4- to 5-fold lower number of immature splenic B cells entering the mature compartment. The combined defects of reduced lifespan and impaired generation in double mutant mice result in a severe deficiency in the mature B cell pool." @default.
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- W2021105966 date "1999-05-01" @default.
- W2021105966 modified "2023-10-02" @default.
- W2021105966 title "Mutations Affecting Either Generation or Survival of Cells Influence the Pool Size of Mature B Cells" @default.
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- W2021105966 doi "https://doi.org/10.1016/s1074-7613(00)80061-8" @default.
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