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- W2021107199 abstract "Abstract Maternal exposure to haloperidol during gestation produced decreased behavioral responsiveness to apomorphine in rat offspring at 10 days after birth, but not at 15 or 30 days. An apparent decrease in the affinity of specific binding of [3H]piroperidol to striatal tissue of rats so treated was observed at 7 days after birth, with no difference in receptor affinity or total binding capacity at 15 or 30 days. Because these effects could result from the continued presence of haloperidol after birth, the distribution and clearance of small quantities of [3H]aloperidol were studied in neonates, older controls, and mothers, up to 10 days after drug administration. The concentration of labelled drug in the brains of the neonates was consistently more than three times higher than in adults, although serum and liver concentrations, and apparent rates of elimination from brain tissue were approximately equal. Postpartum persistence of prenatally administered neuroleptics may account for transient behavioral and biochemical alterations." @default.
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- W2021107199 title "Effects of prenatal treatment of rats with haloperidol due to altered drug distribution in neonatal brain" @default.
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