FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021107923> ?p ?o ?g. }

• W2021107923 endingPage "365" @default.
• W2021107923 startingPage "351" @default.
• W2021107923 abstract "The effects of anti-CD2 monoclonal antibodies (mAb) on anti-CD3-driven interleukin 2 (IL2) production and IL2 receptor (IL2R) expression were investigated. Two anti-CD2 mAb, which had previously been shown to inhibit in vitro anti-CD3-induced T cell proliferation, also inhibited anti-CD3-induced IL2 production. However, it seemed unlikely that this was the crucial mechanism in the inhibition of anti-CD3-driven proliferation, since anti-CD2 mAb also partially inhibited T cell proliferation induced by the anti-CD3 mAb 446 which does not induce detectable IL2 levels. Anti-CD2 mAb also inhibited anti-CD3-induced surface IL2R expression as measured by immunofluorescence staining with an anti-IL2R mAb against the p55 chain. Inhibition of IL2R expression paralleled inhibition of proliferation. This anti-CD2-mediated inhibition involved a block in the generation of normal numbers of IL2R+ cells rather than a direct inhibitory effect on the IL2R+ cells themselves, since IL2R+ cells isolated from anti-CD2-containing cultures responded normally to IL2. Exogenous IL2 and IL4, singly or in combination, could reverse neither the anti-CD2-mediated inhibition of anti-CD3-induced proliferation nor the anti-CD2-mediated inhibition of anti-CD3-induced IL2R expression. Taken together, these observations suggest that anti-CD2 mAb inhibit anti-CD3-driven proliferation by inhibiting the generation of IL2R+ cells at a maturational stage proximal to their expression of surface IL2R. This inhibition cannot be overcome by exogenous IL2 or IL4, suggesting that the underlying biochemical mechanism involves an IL2- and IL4-independent pathway." @default.
• W2021107923 created "2016-06-24" @default.
• W2021107923 creator A5019245481 @default.
• W2021107923 creator A5087173321 @default.
• W2021107923 date "1989-05-01" @default.
• W2021107923 modified "2023-09-26" @default.
• W2021107923 title "Inhibitory effects of anti-CD2 monoclonal antibodies on interleukin 2 production and interleukin 2 receptor expression in anti-CD3-induced T cell activation" @default.
• W2021107923 cites W1484982928 @default.
• W2021107923 cites W1498051162 @default.
• W2021107923 cites W1505706582 @default.
• W2021107923 cites W1506157243 @default.
• W2021107923 cites W1518277493 @default.
• W2021107923 cites W1542310194 @default.
• W2021107923 cites W1543938595 @default.
• W2021107923 cites W1557037773 @default.
• W2021107923 cites W1560071173 @default.
• W2021107923 cites W1563434511 @default.
• W2021107923 cites W1566541473 @default.
• W2021107923 cites W1578987001 @default.
• W2021107923 cites W1592585512 @default.
• W2021107923 cites W1599880469 @default.
• W2021107923 cites W1603765985 @default.
• W2021107923 cites W1613995663 @default.
• W2021107923 cites W1674177895 @default.
• W2021107923 cites W1750984047 @default.
• W2021107923 cites W1798898372 @default.
• W2021107923 cites W1864130549 @default.
• W2021107923 cites W1928575782 @default.
• W2021107923 cites W1930416079 @default.
• W2021107923 cites W1966175492 @default.
• W2021107923 cites W1978946401 @default.
• W2021107923 cites W2000530457 @default.
• W2021107923 cites W2014794045 @default.
• W2021107923 cites W2016620180 @default.
• W2021107923 cites W2018939247 @default.
• W2021107923 cites W2031812880 @default.
• W2021107923 cites W2040685102 @default.
• W2021107923 cites W2065270456 @default.
• W2021107923 cites W2072418891 @default.
• W2021107923 cites W2074529126 @default.
• W2021107923 cites W2093505742 @default.
• W2021107923 cites W2093611967 @default.
• W2021107923 cites W2096089602 @default.
• W2021107923 cites W2099766981 @default.
• W2021107923 cites W2104498491 @default.
• W2021107923 cites W2108391599 @default.
• W2021107923 cites W2113096736 @default.
• W2021107923 cites W2115945544 @default.
• W2021107923 cites W2118050331 @default.
• W2021107923 cites W2143139324 @default.
• W2021107923 cites W2149836164 @default.
• W2021107923 cites W2151419687 @default.
• W2021107923 cites W2155826396 @default.
• W2021107923 cites W2159980878 @default.
• W2021107923 cites W2160434651 @default.
• W2021107923 cites W2396310878 @default.
• W2021107923 cites W2400586427 @default.
• W2021107923 cites W2012972950 @default.
• W2021107923 doi "https://doi.org/10.1016/0008-8749(89)90203-7" @default.
• W2021107923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2566387" @default.
• W2021107923 hasPublicationYear "1989" @default.
• W2021107923 type Work @default.
• W2021107923 sameAs 2021107923 @default.
• W2021107923 citedByCount "5" @default.
• W2021107923 crossrefType "journal-article" @default.
• W2021107923 hasAuthorship W2021107923A5019245481 @default.
• W2021107923 hasAuthorship W2021107923A5087173321 @default.
• W2021107923 hasConcept C114684123 @default.
• W2021107923 hasConcept C153911025 @default.
• W2021107923 hasConcept C159654299 @default.
• W2021107923 hasConcept C167672396 @default.
• W2021107923 hasConcept C170493617 @default.
• W2021107923 hasConcept C191732599 @default.
• W2021107923 hasConcept C203014093 @default.
• W2021107923 hasConcept C2776090121 @default.
• W2021107923 hasConcept C2777371288 @default.
• W2021107923 hasConcept C2778690821 @default.
• W2021107923 hasConcept C2993002077 @default.
• W2021107923 hasConcept C542903549 @default.
• W2021107923 hasConcept C55493867 @default.
• W2021107923 hasConcept C79484868 @default.
• W2021107923 hasConcept C86803240 @default.
• W2021107923 hasConcept C8891405 @default.
• W2021107923 hasConcept C95444343 @default.
• W2021107923 hasConceptScore W2021107923C114684123 @default.
• W2021107923 hasConceptScore W2021107923C153911025 @default.
• W2021107923 hasConceptScore W2021107923C159654299 @default.
• W2021107923 hasConceptScore W2021107923C167672396 @default.
• W2021107923 hasConceptScore W2021107923C170493617 @default.
• W2021107923 hasConceptScore W2021107923C191732599 @default.
• W2021107923 hasConceptScore W2021107923C203014093 @default.
• W2021107923 hasConceptScore W2021107923C2776090121 @default.
• W2021107923 hasConceptScore W2021107923C2777371288 @default.
• W2021107923 hasConceptScore W2021107923C2778690821 @default.
• W2021107923 hasConceptScore W2021107923C2993002077 @default.
• W2021107923 hasConceptScore W2021107923C542903549 @default.
• W2021107923 hasConceptScore W2021107923C55493867 @default.
• W2021107923 hasConceptScore W2021107923C79484868 @default.

• next