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- W2021119900 abstract "Excessive fat storage (obesity) is associated with insulin resistance and type 2 diabetes (1). Paradoxically, inability to store fat (lipodystrophy) is also associated with insulin resistance (2). In both obesity and lipodystrophy, the adipocyte’s storage capacity is exceeded and lipids accumulate in liver, muscle, and β-cells. Hypothetically, if adipose tissue had an intrinsic propensity to proliferate, rather than passively respond to energy excess, calories should be extracted from the circulation and the system should become (or remain) insulin sensitive. Such a process would be particularly effective if it occurred preferentially in subcutaneous adipose tissue, which, metabolically, is the least harmful site (3).We performed extensive metabolic studies in two patients (Table 1) with multiple symmetric lipomatosis (MSL), a condition characterized by regional excess of subcutaneous adipose tissue (4).Patient 1 had massive symmetrical subcutaneous fat accumulation in the thoracic, abdominal, and upper arm region (Fig. 1 A ) that had begun to develop about 15 years earlier. Patient …" @default.
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- W2021119900 date "2004-03-01" @default.
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- W2021119900 title "Multiple Symmetric Lipomatosis" @default.
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- W2021119900 doi "https://doi.org/10.2337/diacare.27.3.794" @default.
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