Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021120588> ?p ?o ?g. }
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- W2021120588 startingPage "81" @default.
- W2021120588 abstract "Age-related macular degeneration (AMD) complicated by subfoveal choroidal neovascularization (CNV) is the leading cause of severe central blindness in developed countries. AMD-related CNVs are distinguishable in classic and occult subtypes, characterized by variable natural history and different responsiveness to therapeutic procedures. Combined and repeated use of photodynamic therapy with verteporfin (PDT-V) and antiangiogenic drugs represents the most promising strategy against neovascular AMD, but it is unavoidably associated with mounting health-resource utilization. Predictive correlations between peculiar coagulation-balance gene variants and different levels of post-PDT-V benefit have recently been documented in Caucasians with AMD-related CNVs. In particular, methylenetetrahydrofolate reductase C677T substitution, a common thrombophilic folate pathway genotypic polymorphism, influences a better CNV responsiveness to PDT-V in classic- but not in occult-CNV cases. These pharmacogenetic findings indicate the opportunities to optimize the eligibility criteria of PDT-V and/or to perform this intriguing therapy in a customized manner, for finally minimizing the socio-economic burden of neovascular AMD." @default.
- W2021120588 created "2016-06-24" @default.
- W2021120588 creator A5023102332 @default.
- W2021120588 creator A5056319932 @default.
- W2021120588 creator A5073312340 @default.
- W2021120588 creator A5084123683 @default.
- W2021120588 creator A5091130945 @default.
- W2021120588 date "2009-01-01" @default.
- W2021120588 modified "2023-09-23" @default.
- W2021120588 title "Predictive role of C677T<i>MTHFR</i>polymorphism in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration" @default.
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