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- W2021124622 abstract "The activity of serum angiotensin converting enzyme (ACE) for healthy horses was 64 +/- 13 mUnits/ml. In vitro, equine serum ACE was sensitive to the following inhibitors (IC50): enalapril (570 nM or 215 ng/ml), captopril (190 nM or 41.3 ng/ml), and enalaprilat (6 nM or 2.1 ng/ml). The intravenous (i.v.) administration of angiotensin I to six healthy horses produced a dose proportional pressor response. The maximal increase in mean arterial pressure over baseline values was 65.6 mmHg at angiotensin I doses of 500 ng/kg bodyweight (bwt). The attenuation of this response to angiotensin I was further demonstrated in a single horse by the prior administration of enalaprilat at an i.v. dose of 8.71 micrograms/kg bwt." @default.
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- W2021124622 date "1989-06-01" @default.
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- W2021124622 title "Serum angiotensin converting enzyme activity and response to angiotensin I in horses" @default.
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- W2021124622 doi "https://doi.org/10.1111/j.2042-3306.1989.tb05662.x" @default.
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