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• W2021127773 abstract "Background— Atherosclerosis is a chronic inflammatory disease that represents the primary cause of death through coronary disease and stroke. Chemokines are known to play a crucial role in this disease by recruiting inflammatory leukocytes to the endothelium. Recently, the chemokine variant [ 44 AANA 47 ]-RANTES was shown to impair inflammatory cell recruitment in vivo by interfering with heparin binding and oligomerization. Methods and Results— In this study we report that curative treatment with [ 44 AANA 47 ]-RANTES limits atherosclerotic plaque formation in LDLr −/− mice. This was associated with reduced infiltration of T cells and macrophages and reduced production of matrix metalloproteinase (MMP)-9. By contrast, the relative smooth muscle cell and collagen content was increased, indicating a more stable plaque phenotype. In addition, we provide evidence for direct inhibition of leukocyte recruitment into aortic root lesions, attenuated leukocyte rolling and arrest in mesenteric vessels, as well as a reduced proinflammatory response following Con A stimulation in vitro. Conclusions— Interference with chemokine oligomerization and chemokine/heparin interactions is a powerful novel approach that inhibits progression of established atherosclerosis in mice. By inhibiting leukocyte recruitment into plaques, [ 44 AANA 47 ]-RANTES mediates a less inflammatory plaque phenotype and thus reduced systemic inflammatory state." @default.
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• W2021127773 date "2008-06-01" @default.
• W2021127773 modified "2023-10-01" @default.
• W2021127773 title "A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice" @default.
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• W2021127773 doi "https://doi.org/10.1161/atvbaha.108.165423" @default.
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