Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021128085> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2021128085 abstract "Myocardial Na,K-ATPase concentration was quantified in 18 0-8-year-old human subjects by vanadate-facilitated 3H-ouabain binding to intact samples of the left ventricle of the heart obtained at autopsy. Within the first 6 months of life, the Na,K-ATPase concentration showed a rapid decrease. The mean value in the age range from birth to 6 months was 1.6 times the mean value obtained in the age range 6 months to 8 years. The mean values +/- SEM were 1,076 +/- 57 (n = 10) and 671 +/- 28 (n = 8) (p less than 0.001) pmol/g wet weight, respectively. The highest value [1,433 +/- 56 pmol/g wet weight (n = 5)] was found in a 3-month-old child and the lowest value [545 +/- 22 pmol/g wet weight (n = 5)] in an 8-year-old. Evaluation of 3H-ouabain-binding kinetics showed no age-dependent variations. The total amount of Na,K-ATPase found in the heart was approximately 30 and 80 nmol within the first 3 years of life and at 8 years, respectively. The age-dependent change in myocardial Na,K-ATPase concentration can be ascribed to variation in the ratio between the amount of Na,K-ATPase and muscle mass during development. Since myocardial Na,K-ATPase is the receptor for cardiac glycosides, the present results may in part explain the clinical observation that cardiac glycoside sensitivity and toxicity change in young age." @default.
- W2021128085 created "2016-06-24" @default.
- W2021128085 creator A5009996527 @default.
- W2021128085 creator A5087047514 @default.
- W2021128085 date "1990-02-01" @default.
- W2021128085 modified "2023-09-27" @default.
- W2021128085 title "Age-Dependent Change in Myocardial Cardiac Glycoside Receptor (Na,K-pump) Concentration in Children" @default.
- W2021128085 doi "https://doi.org/10.1097/00005344-199002000-00022" @default.
- W2021128085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1689431" @default.
- W2021128085 hasPublicationYear "1990" @default.
- W2021128085 type Work @default.
- W2021128085 sameAs 2021128085 @default.
- W2021128085 citedByCount "17" @default.
- W2021128085 countsByYear W20211280852016 @default.
- W2021128085 crossrefType "journal-article" @default.
- W2021128085 hasAuthorship W2021128085A5009996527 @default.
- W2021128085 hasAuthorship W2021128085A5087047514 @default.
- W2021128085 hasConcept C126322002 @default.
- W2021128085 hasConcept C134018914 @default.
- W2021128085 hasConcept C140793950 @default.
- W2021128085 hasConcept C147583825 @default.
- W2021128085 hasConcept C170493617 @default.
- W2021128085 hasConcept C178790620 @default.
- W2021128085 hasConcept C181199279 @default.
- W2021128085 hasConcept C185592680 @default.
- W2021128085 hasConcept C194671627 @default.
- W2021128085 hasConcept C23265538 @default.
- W2021128085 hasConcept C2778921608 @default.
- W2021128085 hasConcept C2779133857 @default.
- W2021128085 hasConcept C2780557390 @default.
- W2021128085 hasConcept C2781116636 @default.
- W2021128085 hasConcept C537181965 @default.
- W2021128085 hasConcept C55493867 @default.
- W2021128085 hasConcept C71240020 @default.
- W2021128085 hasConcept C71924100 @default.
- W2021128085 hasConcept C86803240 @default.
- W2021128085 hasConceptScore W2021128085C126322002 @default.
- W2021128085 hasConceptScore W2021128085C134018914 @default.
- W2021128085 hasConceptScore W2021128085C140793950 @default.
- W2021128085 hasConceptScore W2021128085C147583825 @default.
- W2021128085 hasConceptScore W2021128085C170493617 @default.
- W2021128085 hasConceptScore W2021128085C178790620 @default.
- W2021128085 hasConceptScore W2021128085C181199279 @default.
- W2021128085 hasConceptScore W2021128085C185592680 @default.
- W2021128085 hasConceptScore W2021128085C194671627 @default.
- W2021128085 hasConceptScore W2021128085C23265538 @default.
- W2021128085 hasConceptScore W2021128085C2778921608 @default.
- W2021128085 hasConceptScore W2021128085C2779133857 @default.
- W2021128085 hasConceptScore W2021128085C2780557390 @default.
- W2021128085 hasConceptScore W2021128085C2781116636 @default.
- W2021128085 hasConceptScore W2021128085C537181965 @default.
- W2021128085 hasConceptScore W2021128085C55493867 @default.
- W2021128085 hasConceptScore W2021128085C71240020 @default.
- W2021128085 hasConceptScore W2021128085C71924100 @default.
- W2021128085 hasConceptScore W2021128085C86803240 @default.
- W2021128085 hasLocation W20211280851 @default.
- W2021128085 hasLocation W20211280852 @default.
- W2021128085 hasOpenAccess W2021128085 @default.
- W2021128085 hasPrimaryLocation W20211280851 @default.
- W2021128085 hasRelatedWork W1979064489 @default.
- W2021128085 hasRelatedWork W1986178764 @default.
- W2021128085 hasRelatedWork W1999688504 @default.
- W2021128085 hasRelatedWork W2018172989 @default.
- W2021128085 hasRelatedWork W2044993987 @default.
- W2021128085 hasRelatedWork W2082645421 @default.
- W2021128085 hasRelatedWork W2197278359 @default.
- W2021128085 hasRelatedWork W2294282582 @default.
- W2021128085 hasRelatedWork W2410141219 @default.
- W2021128085 hasRelatedWork W2415678208 @default.
- W2021128085 isParatext "false" @default.
- W2021128085 isRetracted "false" @default.
- W2021128085 magId "2021128085" @default.
- W2021128085 workType "article" @default.