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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021128180> ?p ?o ?g. }

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• W2021128180 abstract "A series of potent novel 8-hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and viral replication in cells. Compound 12 is active against replication of HIV-1 in cell culture with a CIC(95) of 0.31microM. Further SAR exploration led to the preparation of pseudosymmetrical tricyclic pyrrolopyrazine inhibitors 23 and 24 with further improvement in antiviral activity." @default.
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• W2021128180 date "2007-12-01" @default.
• W2021128180 modified "2023-10-01" @default.
• W2021128180 title "8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors" @default.
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• W2021128180 doi "https://doi.org/10.1016/j.bmcl.2007.09.086" @default.
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