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• W2021128465 startingPage "68" @default.
• W2021128465 abstract "The molecular mechanism(s) underlying transition from CCR5 to CXCR4 usage of subtype C viruses remain largely unknown. We previously identified a subtype C HIV-1 infected child whose virus demonstrated CXCR4 usage along with CCR5 upon longitudinal follow-up. Here we delineated the molecular determinants of Env involved in expanded coreceptor usage. Residue changes in three positions of Env V3 domain are critical for the dual tropic phenotype. These include: substitution of arginine at position 11, MG or LG insertion between positions 13 and 14, and substitution of threonine at the position immediately downstream of the GPGQ crown. Introducing these mutations into V3 region of a heterologous R5 virus also conferred dual tropism. Molecular modeling of V3 revealed a possible structural basis for the dual tropic phenotype. Determining what defines a subtype C X4 virus will lead to a better understanding of subtype C HIV-1 pathogenesis, and will provide important information relevant to anti-retroviral therapy." @default.
• W2021128465 created "2016-06-24" @default.
• W2021128465 creator A5018071732 @default.
• W2021128465 creator A5041528294 @default.
• W2021128465 creator A5058666321 @default.
• W2021128465 creator A5062109156 @default.
• W2021128465 creator A5065375803 @default.
• W2021128465 creator A5069849278 @default.
• W2021128465 date "2010-11-01" @default.
• W2021128465 modified "2023-09-29" @default.
• W2021128465 title "Molecular determinants of HIV-1 subtype C coreceptor transition from R5 to R5X4" @default.
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• W2021128465 doi "https://doi.org/10.1016/j.virol.2010.07.047" @default.
• W2021128465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2947837" @default.
• W2021128465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20797755" @default.
• W2021128465 hasPublicationYear "2010" @default.
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