Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021129076> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2021129076 endingPage "769" @default.
- W2021129076 startingPage "760" @default.
- W2021129076 abstract "Objective: The aim was to study the locations and functions of atrial and ventricular nicotine sensitive neurones. Methods: In anaesthetised open chest dogs, cardiovascular effects elicited by nicotine (100 μg in 0.1 ml 0.9% saline), administered at specific loci of in situ atrial and ventricular ganglionated plexi, were studied before and after decentralisation. Results: Cardiovascular responses were elicited when 41 % of atrial and 36% of ventricular ganglionated plexus loci were studied. Subsequently, ganglia were identified adjacent to active sites. When cardiovascular responses were elicited, either tachycardia or bradycardia was induced, depending on the locus investigated. When tachycardia occurred, atrial and/or ventricular forces were augmented. When bradycardia occurred, atrial forces were suppressed. Ventricular fibrillation was induced in two animals when ventricular ganglionated plexus loci were investigated. Cardiovascular responses were not elicited when up to 2000 μg of nicotine were administered adjacent to intrinsic cardiac axons, indicating that responses were not primarily due to axonal effects. Control injections of saline (0.1 ml) into active loci did not elicit cardiovascular responses. Following acute decentralisation, responses initiated by nicotine were attenuated or eliminated. Depressor responses were no longer elicited following atropine administration, nor augmentor ones following propranolol administration. Conclusions: (1) The canine heart contains nicotine sensitive neurones which can induce either augmentor or depressor cardiac effects. (2) Nicotine sensitive atrial neurones modify primarily, but not exclusively, atrial tissues, whereas ventricular ones modify primarily, but not exclusively, ventricular tissues. (3) Nicotine sensitive intrinsic cardiac neurones can interact with central neurones to modulate the heart. Cardiovascular Research 1993;27:760-769" @default.
- W2021129076 created "2016-06-24" @default.
- W2021129076 creator A5016418904 @default.
- W2021129076 creator A5038595912 @default.
- W2021129076 creator A5078436656 @default.
- W2021129076 creator A5089910234 @default.
- W2021129076 date "1993-05-01" @default.
- W2021129076 modified "2023-10-17" @default.
- W2021129076 title "Differential cardiac responses induced by nicotine sensitive canine atrial and ventricular neurones" @default.
- W2021129076 doi "https://doi.org/10.1093/cvr/27.5.760" @default.
- W2021129076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8348576" @default.
- W2021129076 hasPublicationYear "1993" @default.
- W2021129076 type Work @default.
- W2021129076 sameAs 2021129076 @default.
- W2021129076 citedByCount "49" @default.
- W2021129076 countsByYear W20211290762013 @default.
- W2021129076 countsByYear W20211290762014 @default.
- W2021129076 countsByYear W20211290762015 @default.
- W2021129076 countsByYear W20211290762016 @default.
- W2021129076 countsByYear W20211290762020 @default.
- W2021129076 countsByYear W20211290762021 @default.
- W2021129076 countsByYear W20211290762022 @default.
- W2021129076 crossrefType "journal-article" @default.
- W2021129076 hasAuthorship W2021129076A5016418904 @default.
- W2021129076 hasAuthorship W2021129076A5038595912 @default.
- W2021129076 hasAuthorship W2021129076A5078436656 @default.
- W2021129076 hasAuthorship W2021129076A5089910234 @default.
- W2021129076 hasConcept C126322002 @default.
- W2021129076 hasConcept C164705383 @default.
- W2021129076 hasConcept C2775859210 @default.
- W2021129076 hasConcept C2776331378 @default.
- W2021129076 hasConcept C2777495988 @default.
- W2021129076 hasConcept C2777953023 @default.
- W2021129076 hasConcept C2778151854 @default.
- W2021129076 hasConcept C2779547902 @default.
- W2021129076 hasConcept C2780283014 @default.
- W2021129076 hasConcept C42219234 @default.
- W2021129076 hasConcept C71924100 @default.
- W2021129076 hasConcept C84393581 @default.
- W2021129076 hasConceptScore W2021129076C126322002 @default.
- W2021129076 hasConceptScore W2021129076C164705383 @default.
- W2021129076 hasConceptScore W2021129076C2775859210 @default.
- W2021129076 hasConceptScore W2021129076C2776331378 @default.
- W2021129076 hasConceptScore W2021129076C2777495988 @default.
- W2021129076 hasConceptScore W2021129076C2777953023 @default.
- W2021129076 hasConceptScore W2021129076C2778151854 @default.
- W2021129076 hasConceptScore W2021129076C2779547902 @default.
- W2021129076 hasConceptScore W2021129076C2780283014 @default.
- W2021129076 hasConceptScore W2021129076C42219234 @default.
- W2021129076 hasConceptScore W2021129076C71924100 @default.
- W2021129076 hasConceptScore W2021129076C84393581 @default.
- W2021129076 hasIssue "5" @default.
- W2021129076 hasLocation W20211290761 @default.
- W2021129076 hasLocation W20211290762 @default.
- W2021129076 hasOpenAccess W2021129076 @default.
- W2021129076 hasPrimaryLocation W20211290761 @default.
- W2021129076 hasRelatedWork W11499719 @default.
- W2021129076 hasRelatedWork W1635333161 @default.
- W2021129076 hasRelatedWork W1979700304 @default.
- W2021129076 hasRelatedWork W1995107262 @default.
- W2021129076 hasRelatedWork W2000519901 @default.
- W2021129076 hasRelatedWork W2013404744 @default.
- W2021129076 hasRelatedWork W2105136510 @default.
- W2021129076 hasRelatedWork W2140637997 @default.
- W2021129076 hasRelatedWork W2428698524 @default.
- W2021129076 hasRelatedWork W35362415 @default.
- W2021129076 hasVolume "27" @default.
- W2021129076 isParatext "false" @default.
- W2021129076 isRetracted "false" @default.
- W2021129076 magId "2021129076" @default.
- W2021129076 workType "article" @default.