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• W2021131299 startingPage "e65874" @default.
• W2021131299 abstract "Changes in the shape of the lung during breathing determine the movement of airways and alveoli, and thus impact airflow dynamics. Modeling airflow dynamics in health and disease is a key goal for predictive multiscale models of respiration. Past efforts to model changes in lung shape during breathing have measured shape at multiple breath-holds. However, breath-holds do not capture hysteretic differences between inspiration and expiration resulting from the additional energy required for inspiration. Alternatively, imaging dynamically – without breath-holds – allows measurement of hysteretic differences. In this study, we acquire multiple micro-CT images per breath (4DCT) in live rats, and from these images we develop, for the first time, dynamic volume maps. These maps show changes in local volume across the entire lung throughout the breathing cycle and accurately predict the global pressure-volume (PV) hysteresis. Male Sprague-Dawley rats were given either a full- or partial-lung dose of elastase or saline as a control. After three weeks, 4DCT images of the mechanically ventilated rats under anesthesia were acquired dynamically over the breathing cycle (11 time points, ≤100 ms temporal resolution, 8 cmH2O peak pressure). Non-rigid image registration was applied to determine the deformation gradient – a numerical description of changes to lung shape – at each time point. The registration accuracy was evaluated by landmark identification. Of 67 landmarks, one was determined misregistered by all three observers, and 11 were determined misregistered by two observers. Volume change maps were calculated on a voxel-by-voxel basis at all time points using both the Jacobian of the deformation gradient and the inhaled air fraction. The calculated lung PV hysteresis agrees with pressure-volume curves measured by the ventilator. Volume maps in diseased rats show increased compliance and ventilation heterogeneity. Future predictive multiscale models of rodent respiration may leverage such volume maps as boundary conditions." @default.
• W2021131299 created "2016-06-24" @default.
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• W2021131299 date "2013-06-14" @default.
• W2021131299 modified "2023-09-23" @default.
• W2021131299 title "Dynamic Multiscale Boundary Conditions for 4D CT of Healthy and Emphysematous Rats" @default.
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• W2021131299 doi "https://doi.org/10.1371/journal.pone.0065874" @default.
• W2021131299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3683027" @default.
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• W2021131299 hasPublicationYear "2013" @default.
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